SRI

This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene.

sorcin

Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.

Biological Process action potentialManual Assertion Based On ExperimentTAS:ProtInc
Biological Process calcium ion transportIEA:Ensembl
Biological Process cytoplasmic sequestering of transcription factorIEA:Ensembl
Biological Process heart developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process intracellular sequestering of iron ionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process muscle organ developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of cardiac muscle contractionIEA:Ensembl
Biological Process negative regulation of heart rateManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of ryanodine-sensitive calcium-release channel activityManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of transcription regulatory region DNA bindingIEA:Ensembl
Biological Process positive regulation of insulin secretion involved in cellular response to glucose stimulusIEA:Ensembl
Biological Process positive regulation of release of sequestered calcium ion into cytosolIEA:Ensembl
Biological Process regulation of calcium ion transportManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of cardiac muscle cell contractionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of cell communication by electrical couplingManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process regulation of cell communication by electrical coupling involved in cardiac conductionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of heart contractionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process regulation of high voltage-gated calcium channel activityManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of relaxation of muscleManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process regulation of striated muscle contractionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process signal transductionManual Assertion Based On ExperimentTAS:UniProtKB

Cytoplasm
Sarcoplasmic reticulum membrane
Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels.