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Mouse Anti-SRI Recombinant Antibody (1E12) (CBMAB-A8595-LY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
1E12
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SRI (AAH11025, 1 a.a. ~ 198 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
sorcin
Entrez Gene ID
Human6717
Mouse109552
Rat683667
UniProt ID
HumanP30626
MouseQ6P069
RatM0RAF3
Alternative Names
FLJ26259; SCN
Function
Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.
Biological Process
Biological Process action potentialManual Assertion Based On ExperimentTAS:ProtInc
Biological Process calcium ion transportIEA:Ensembl
Biological Process cytoplasmic sequestering of transcription factorIEA:Ensembl
Biological Process heart developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process intracellular sequestering of iron ionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process muscle organ developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of cardiac muscle contractionIEA:Ensembl
Biological Process negative regulation of heart rateManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of ryanodine-sensitive calcium-release channel activityManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of transcription regulatory region DNA bindingIEA:Ensembl
Biological Process positive regulation of insulin secretion involved in cellular response to glucose stimulusIEA:Ensembl
Biological Process positive regulation of release of sequestered calcium ion into cytosolIEA:Ensembl
Biological Process regulation of calcium ion transportManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of cardiac muscle cell contractionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of cell communication by electrical couplingManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process regulation of cell communication by electrical coupling involved in cardiac conductionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of heart contractionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process regulation of high voltage-gated calcium channel activityManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of relaxation of muscleManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process regulation of striated muscle contractionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process signal transductionManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Cytoplasm
Sarcoplasmic reticulum membrane
Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels.
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For research use only. Not intended for any clinical use.

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