SRPRB
The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane.
Full Name
SRP Receptor Beta Subunit
Function
Component of the signal recognition particle (SRP) complex receptor (SR) (By similarity).
Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity).
May mediate the membrane association of SR (By similarity).
Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity).
May mediate the membrane association of SR (By similarity).
Biological Process
Biological Process protein targeting to ERManual Assertion Based On ExperimentIBA:GO_Central
Biological Process SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition1 PublicationIC:ComplexPortal
Biological Process SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition1 PublicationIC:ComplexPortal
Cellular Location
Endoplasmic reticulum membrane
Topology
Helical: 37-57
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Anti-SRPRB antibodies
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Target: SRPRB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5181
Application*: WB
Target: SRPRB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4505
Application*: P, WB
Target: SRPRB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4496
Application*: WB, IH
Target: SRPRB
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4419
Application*: P, WB
Target: SRPRB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4023
Application*: WB, F, IH, P
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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