SRSF10

This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants.

Full Name

Serine And Arginine Rich Splicing Factor 10

Function

Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198).
Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198).
Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198).
Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937).
Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937).
May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250).

Biological Process

Biological Process cytosolic transportIEA:Ensembl
Biological Process mRNA splice site selectionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of DNA-templated transcription1 PublicationNAS:UniProtKB
Biological Process regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process RNA splicing, via transesterification reactionsManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process spliceosomal tri-snRNP complex assembly1 PublicationNAS:UniProtKB

Cellular Location

Nucleus speckle
Cytoplasm

PTM

Phosphorylated. Fully dephosphorylated in mitosis and partially dephosphorylated on heat shock.