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STMN1

This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene.
Full Name
stathmin 1
Function
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).
Biological Process
AxonogenesisIEA:Ensembl
Establishment of skin barrierManual Assertion Based On ExperimentIMP:CAFA
Hepatocyte growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:CAFA
Intracellular signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Microtubule depolymerizationManual Assertion Based On ExperimentIDA:MGI
Mitotic cytokinesisManual Assertion Based On ExperimentIMP:GO_Central
Mitotic spindle organizationManual Assertion Based On ExperimentIDA:MGI
Negative regulation of guanyl-nucleotide exchange factor activityManual Assertion Based On ExperimentIMP:CAFA
Negative regulation of microtubule polymerizationManual Assertion Based On ExperimentIMP:CAFA
Negative regulation of Rho protein signal transductionManual Assertion Based On ExperimentIMP:CAFA
Negative regulation of stress fiber assemblyManual Assertion Based On ExperimentIMP:CAFA
Negative regulation of thrombin-activated receptor signaling pathwayManual Assertion Based On ExperimentIMP:CAFA
Neuron projection developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cellular component movementIEA:Ensembl
Regulation of microtubule polymerization or depolymerizationManual Assertion Based On ExperimentIMP:CAFA
Response to virusManual Assertion Based On ExperimentIEP:UniProtKB
Signal transduction1 PublicationNAS:ProtInc
Cellular Location
Cytoplasm, cytoskeleton
PTM
Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity).
Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity.
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Anti-STMN1 antibodies

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Rabbit Anti-STMN1 Monoclonal Antibody (EP1572) (CBMAB-1563-YC)

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Target: STMN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EP1572
Application*: P, IC, IP, F, WB
Datasheet SDS

Rabbit Anti-STMN1 Monoclonal Antibody (EP2124Y) (CBMAB-1748-YC)

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Target: STMN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EP2124Y
Application*: IC, WB
Datasheet SDS

Rabbit Anti-STMN1 Monoclonal Antibody (EP1573Y) (CBMAB-1562-YC)

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Target: STMN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EP1573Y
Application*: F, IC, IF, P, IP, WB
Datasheet SDS

Rabbit Anti-STMN1 Monoclonal Antibody (SP49) (CBMAB-1561-YC)

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Target: STMN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: SP49
Application*: F, P, WB
Datasheet SDS

Rabbit Anti-STMN1 Recombinant Antibody (EG1454) (CBMAB-EN1735-LY)

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Target: STMN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1454
Application*: WB: 1:500~1:1000 ELISA: 1:40000
Datasheet SDS

Mouse Anti-STMN1 Recombinant Antibody (CF413) (CBMAB-FT108LY)

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Target: STMN1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CF413
Application*: ELISA, WB, IHC, IF
Datasheet SDS

Rabbit Anti-STMN1 Recombinant Antibody (RM350) (CBMAB-BR458LY)

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Target: STMN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: RM350
Application*: IHC, WB
Datasheet SDS

Rabbit Anti-STMN1 Recombinant Antibody (D1Y5A) (CBMAB-CP2622-LY)

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Target: STMN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D1Y5A
Application*: WB, P, IF (IC)
Datasheet SDS

Rabbit Anti-STMN1 (Phosphorylated S38) Recombinant Antibody (D19H10) (PTM-CBMAB-0118LY)

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Target: STMN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: D19H10
Application*: WB, IP, P, IF
Datasheet SDS

Rabbit Anti-STMN1 Recombinant Antibody (CBXS-1407) (CBMAB-S4265-CQ)

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Target: STMN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1407
Application*: WB, IP, P
Datasheet SDS

Rabbit Anti-STMN1 Recombinant Antibody (CBXS-1190) (CBMAB-S4056-CQ)

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Target: STMN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1190
Application*: WB, IC
Datasheet SDS

Rabbit Anti-STMN1 Recombinant Antibody (CBXS-1182) (CBMAB-S4052-CQ)

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Target: STMN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1182
Application*: WB, IP, P, IC, F
Datasheet SDS

Rabbit Anti-STMN1 Recombinant Antibody (CBXS-0801) (CBMAB-S3728-CQ)

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Target: STMN1
Host: Rabbit
Specificity: Human, Mouse, Rat
Clone: CBXS-0801
Application*: WB, P, IF
Datasheet SDS

Mouse Anti-STMN1 Recombinant Antibody (CBXS-4754) (CBMAB-S1983-CQ)

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Target: STMN1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBXS-4754
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-STMN1 Recombinant Antibody (CBXS-5878) (CBMAB-S0729-CQ)

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Target: STMN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBXS-5878
Application*: E, IF, IH, WB, IR
Datasheet SDS

Rabbit Anti-STMN1 Recombinant Antibody (CBXS-1183) (CBMAB-S0318-CQ)

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Target: STMN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: CBXS-1183
Application*: WB
Datasheet SDS

Mouse Anti-STMN1 Recombinant Antibody (CBYJL-2354) (CBMAB-L2660-YJ)

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Target: STMN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-2354
Application*: WB, IC, P, C, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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