Rabbit Anti-STMN1 Monoclonal Antibody (EP1572) (CBMAB-1563-YC)

Name: Rabbit Anti-STMN1 Monoclonal Antibody (EP1572)
SKU: CBMAB-1563-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

EP1572

Application

IHC-P, ICC, IP, FC, WB

Immunogen

Synthetic peptide corresponding to residues at the N-terminus in Human Stathmin 1.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

stathmin 1

Introduction

STMN1 is a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment which is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules.

Entrez Gene ID

Human	3925
Mouse	16765
Rat	29332

UniProt ID

Human	P16949
Mouse	P54227
Rat	P13668

Alternative Names

Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215

Function

Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).

Biological Process

AxonogenesisIEA:Ensembl
Establishment of skin barrierManual Assertion Based On ExperimentIMP:CAFA
Hepatocyte growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:CAFA
Intracellular signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Microtubule depolymerizationManual Assertion Based On ExperimentIDA:MGI
Mitotic cytokinesisManual Assertion Based On ExperimentIMP:GO_Central
Mitotic spindle organizationManual Assertion Based On ExperimentIDA:MGI
Negative regulation of guanyl-nucleotide exchange factor activityManual Assertion Based On ExperimentIMP:CAFA
Negative regulation of microtubule polymerizationManual Assertion Based On ExperimentIMP:CAFA
Negative regulation of Rho protein signal transductionManual Assertion Based On ExperimentIMP:CAFA
Negative regulation of stress fiber assemblyManual Assertion Based On ExperimentIMP:CAFA
Negative regulation of thrombin-activated receptor signaling pathwayManual Assertion Based On ExperimentIMP:CAFA
Neuron projection developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cellular component movementIEA:Ensembl
Regulation of microtubule polymerization or depolymerizationManual Assertion Based On ExperimentIMP:CAFA
Response to virusManual Assertion Based On ExperimentIEP:UniProtKB
Signal transduction1 PublicationNAS:ProtInc

Cellular Location

Cytoplasm, cytoskeleton

PTM

Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity).
Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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