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Rabbit Anti-STMN1 Monoclonal Antibody (SP49) (CBMAB-1561-YC)

Provided herein is a rabbit monoclonal antibody against Human STMN1. The antibody, clone SP49, can be used for immunoassay techniques, such as FC, IHC-P and WB.
See all STMN1 antibodies
Published Data
Fig.1 Western blotting results showed that the expression levels of MYL1, MYL3, and TNNT3 all increased, while RPS3A and STMN1 decreased from E11 to D1.
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Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
SP49
Antibody Isotype
IgG
Application
FC, IHC-P, WB

Basic Information

Immunogen
A synthetic peptide derived from the internal region of Human Stathmin 1
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
stathmin 1
Introduction
STMN1 is a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment which is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules.
Entrez Gene ID
Human3925
Mouse16765
UniProt ID
HumanP16949
MouseP54227
Alternative Names
Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215
Function
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).
Biological Process
AxonogenesisIEA:Ensembl
Establishment of skin barrierManual Assertion Based On ExperimentIMP:CAFA
Hepatocyte growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:CAFA
Intracellular signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Microtubule depolymerizationManual Assertion Based On ExperimentIDA:MGI
Mitotic cytokinesisManual Assertion Based On ExperimentIMP:GO_Central
Mitotic spindle organizationManual Assertion Based On ExperimentIDA:MGI
Negative regulation of guanyl-nucleotide exchange factor activityManual Assertion Based On ExperimentIMP:CAFA
Negative regulation of microtubule polymerizationManual Assertion Based On ExperimentIMP:CAFA
Negative regulation of Rho protein signal transductionManual Assertion Based On ExperimentIMP:CAFA
Negative regulation of stress fiber assemblyManual Assertion Based On ExperimentIMP:CAFA
Negative regulation of thrombin-activated receptor signaling pathwayManual Assertion Based On ExperimentIMP:CAFA
Neuron projection developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cellular component movementIEA:Ensembl
Regulation of microtubule polymerization or depolymerizationManual Assertion Based On ExperimentIMP:CAFA
Response to virusManual Assertion Based On ExperimentIEP:UniProtKB
Signal transduction1 PublicationNAS:ProtInc
Cellular Location
Cytoplasm, cytoskeleton
PTM
Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity).
Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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