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SULT1A1

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene.
Full Name
sulfotransferase family 1A member 1
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine groupe. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones and 3,3'-diiodothyronin (PubMed:16221673, PubMed:12471039, PubMed:22069470, PubMed:21723874, PubMed:10199779, PubMed:7834621).
Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil (By similarity).
Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed:7834621).
May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system.
Biological Process
Biological Process 3'-phosphoadenosine 5'-phosphosulfate metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process amine metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process catecholamine metabolic processIEA:UniProtKB-KW
Biological Process estrogen metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process ethanol catabolic processManual Assertion Based On ExperimentIDA:CAFA
Biological Process flavonoid metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process sulfationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process xenobiotic metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
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Anti-SULT1A1 antibodies

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Mouse Anti-SULT1A1 Recombinant Antibody (CF417) (CBMAB-FT095LY)

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Target: SULT1A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CF417
Application*: ELISA, WB
Datasheet SDS

Rabbit Anti-SULT1A1 Recombinant Antibody (CBXS-1405) (CBMAB-S4263-CQ)

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Target: SULT1A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1405
Application*: WB
Datasheet SDS

Rabbit Anti-SULT1A1 Recombinant Antibody (CBXS-1123) (CBMAB-S4007-CQ)

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Target: SULT1A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1123
Application*: P
Datasheet SDS

Rabbit Anti-SULT1A1 Recombinant Antibody (CBXS-1110) (CBMAB-S3996-CQ)

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Target: SULT1A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1110
Application*: E
Datasheet SDS

Mouse Anti-SULT1A1 Recombinant Antibody (CBXS-0844) (CBMAB-S3768-CQ)

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Target: SULT1A1
Host: Mouse
Specificity: Rat
Clone: CBXS-0844
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-SULT1A1 Recombinant Antibody (CBXS-0843) (CBMAB-S3767-CQ)

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Target: SULT1A1
Host: Mouse
Specificity: Human
Clone: CBXS-0843
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-SULT1A1 Recombinant Antibody (CBXS-5173) (CBMAB-S2391-CQ)

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Target: SULT1A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5173
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-SULT1A1 Recombinant Antibody (CBXS-5128) (CBMAB-S2346-CQ)

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Target: SULT1A1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-5128
Application*: P, WB
Datasheet SDS

Mouse Anti-SULT1A1 Recombinant Antibody (CBXS-4884) (CBMAB-S2107-CQ)

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Target: SULT1A1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Mouse, Rat
Clone: CBXS-4884
Application*: IP
Datasheet SDS

Mouse Anti-SULT1A1 Recombinant Antibody (CBXS-4812) (CBMAB-S2038-CQ)

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Target: SULT1A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4812
Application*: WB, E, IP
Datasheet SDS

Mouse Anti-SULT1A1 Recombinant Antibody (CBXS-4446) (CBMAB-S1688-CQ)

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Target: SULT1A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4446
Application*: F, IF, P, WB
Datasheet SDS

Rabbit Anti-SULT1A1 Recombinant Antibody (CBXS-4310) (CBMAB-S1555-CQ)

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Target: SULT1A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-4310
Application*: E
Datasheet SDS

Mouse Anti-SULT1A1 Recombinant Antibody (CBXS-4150) (CBMAB-S1403-CQ)

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Target: SULT1A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4150
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-SULT1A1 Recombinant Antibody (CBXS-4136) (CBMAB-S1390-CQ)

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Target: SULT1A1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBXS-4136
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-SULT1A1 Recombinant Antibody (CBXS-3633) (CBMAB-S0915-CQ)

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Target: SULT1A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-3633
Application*: E, WB
Datasheet SDS

Mouse Anti-SULT1A1 Recombinant Antibody (CBXS-5964) (CBMAB-S0811-CQ)

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Target: SULT1A1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-5964
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-SULT1A1 Recombinant Antibody (CBXS-5962) (CBMAB-S0809-CQ)

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Target: SULT1A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5962
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-SULT1A1 Recombinant Antibody (CBXS-5924) (CBMAB-S0773-CQ)

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Target: SULT1A1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-5924
Application*: F, P, WB
Datasheet SDS

Mouse Anti-SULT1A1 Recombinant Antibody (CBXS-5807) (CBMAB-S0663-CQ)

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Target: SULT1A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5807
Application*: F, WB
Datasheet SDS

Mouse Anti-SULT1A1 Recombinant Antibody (CBXS-5781) (CBMAB-S0640-CQ)

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Target: SULT1A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5781
Application*: P, IP, WB
Datasheet SDS

Mouse Anti-SULT1A1 Recombinant Antibody (CBYY-C0499) (CBMAB-C1489-YY)

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Target: SULT1A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0499
Application*: WB, IH, IP
Datasheet SDS

Mouse Anti-SULT1A1 Recombinant Antibody (CBWJC-4467) (CBMAB-C5859WJ)

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Target: SULT1A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4467
Application*: WB, F, IH, IC, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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