SULT1B1

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. However, the total genomic length of this gene is greater than that of other SULT1 genes.

Full Name

Sulfotransferase Family 1B Member 1

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3) (PubMed:28084139, PubMed:9443824, PubMed:9463486).
May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (PubMed:35165440).

Biological Process

Biological Process 3'-phosphoadenosine 5'-phosphosulfate metabolic processManual Assertion Based On ExperimentIDA:CAFA
Biological Process cellular biogenic amine metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process epithelial cell differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process ethanol catabolic processManual Assertion Based On ExperimentIDA:CAFA
Biological Process flavonoid metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process phenol-containing compound metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process sulfationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process thyroid hormone metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process xenobiotic metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

Cytoplasm