SUPV3L1

SUPV3L1 (Suv3 Like RNA Helicase) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA binding.

Full Name

Suv3 Like RNA Helicase

Function

Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381).
ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.

Biological Process

Biological Process DNA duplex unwindingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process DNA recombinationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitochondrial mRNA catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitochondrial mRNA surveillanceManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitochondrial ncRNA surveillanceManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitochondrial RNA 3'-end processingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitochondrial RNA surveillanceManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitochondrion morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of cell growthManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of mitochondrial RNA catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process RNA catabolic processManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus
Mitochondrion matrix
Mitochondrion matrix, mitochondrion nucleoid