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SYNC

This gene encodes a member of the intermediate filament family which contains an N-terminal head domain, followed by a central coiled-coil region and a short C-terminal tail. The protein is highly expressed in skeletal and cardiac muscle. The protein links the dystrophin associated protein complex (DAPC) to desmin filaments in muscle and may have a structural role in striated muscle. Multiple transcript variants encoding different isoforms have been found for this gene.

Full Name

Syncoilin, Intermediate Filament Protein

Function

Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins.

Biological Process

Intermediate filament-based process

Cellular Location

Cytoplasm, perinuclear region
In skeletal muscle, colocalizes with DES and DTNA, and is localized at the myotendinous and neuromuscular junctions, sarcolemma and Z-lines. In myotubes, detected in a punctate cytoplasmic pattern (By similarity).

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Anti-SYNC antibodies

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Mouse Anti-SYNC Recombinant Antibody (CBXS-2097) (CBMAB-S4862-CQ)

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Target: SYNC

Host: Mouse

Specificity: Human

Clone: CBXS-2097

Application*: WB, IP, IF, E

Mouse Anti-SYNC Recombinant Antibody (CBXS-5147) (CBMAB-S2365-CQ)

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Target: SYNC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-5147

Application*: WB, IH

Mouse Anti-SYNC Recombinant Antibody (CBXS-5038) (CBMAB-S2259-CQ)

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Target: SYNC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-5038

Application*: WB

Mouse Anti-SYNC Recombinant Antibody (CBXS-4076) (CBMAB-S1334-CQ)

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Target: SYNC

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXS-4076

Application*: WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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