TAB1

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

TAB1 Gene(Protein Coding) TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1

May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

Biological Process aorta developmentIEA:Ensembl
Biological Process cardiac septum developmentIEA:Ensembl
Biological Process coronary vasculature developmentIEA:Ensembl
Biological Process heart morphogenesisIEA:Ensembl
Biological Process in utero embryonic developmentIEA:Ensembl
Biological Process lung developmentIEA:Ensembl
Biological Process positive regulation of MAP kinase activityIEA:Ensembl
Biological Process positive regulation of protein serine/threonine kinase activityIDA:UniProtKB1 Publication
Biological Process transforming growth factor beta receptor signaling pathwayIEA:Ensembl

Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP.