TAB1

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Full Name

TAB1 Gene(Protein Coding) TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1

Function

May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

Biological Process

Biological Process aorta developmentIEA:Ensembl
Biological Process cardiac septum developmentIEA:Ensembl
Biological Process coronary vasculature developmentIEA:Ensembl
Biological Process heart morphogenesisIEA:Ensembl
Biological Process in utero embryonic developmentIEA:Ensembl
Biological Process lung developmentIEA:Ensembl
Biological Process positive regulation of MAP kinase activityIEA:Ensembl
Biological Process positive regulation of protein serine/threonine kinase activityIDA:UniProtKB1 Publication
Biological Process transforming growth factor beta receptor signaling pathwayIEA:Ensembl

PTM

Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP.

Anti-TAB1 antibodies

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Mouse Anti-TAB1 Recombinant Antibody (CB10A) (CBMAB-CA010LY)

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Target: TAB1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Dog, Mouse, Pig, Rat

Clone: CB10A

Application*: ELISA, WB

Datasheet SDS

Rabbit Anti-TAB1 Recombinant Antibody (C25E9) (CBMAB-CP2677-LY)

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Target: TAB1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Monkey

Clone: C25E9

Application*: WB, IP

Datasheet SDS

Mouse Anti-TAB1 Recombinant Antibody (2A12) (CBMAB-A5222-LY)

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Target: TAB1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Rat

Clone: 2A12

Application*: WB, E

Datasheet SDS

Mouse Anti-TAB1 Recombinant Antibody (3D10-G10-B6) (CBMAB-Z0257-LY)

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Target: TAB1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 3D10-G10-B6

Application*: WB

Datasheet SDS

Mouse Anti-TAB1 Recombinant Antibody (CBYJT-1751) (CBMAB-T0812-YJ)

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Target: TAB1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Rat

Clone: CBYJT-1751

Application*: E, IF, WB

Datasheet SDS

Mouse Anti-TAB1 Recombinant Antibody (CBYJT-1748) (CBMAB-T0809-YJ)

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Target: TAB1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBYJT-1748

Application*: E, WB

Datasheet SDS

Rabbit Anti-TAB1 Recombinant Antibody (CBYJT-1747) (CBMAB-T0808-YJ)

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Target: TAB1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Monkey

Clone: CBYJT-1747

Application*: IP, WB

Datasheet SDS

Mouse Anti-TAB1 Recombinant Antibody (CBYJT-1746) (CBMAB-T0807-YJ)

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Target: TAB1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-1746

Application*: WB

Datasheet SDS

Mouse Anti-TAB1 Recombinant Antibody (CBYJT-1745) (CBMAB-T0806-YJ)

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Target: TAB1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJT-1745

Application*: E, WB

Datasheet SDS

Mouse Anti-TAB1 Recombinant Antibody (CBYJT-1744) (CBMAB-T0805-YJ)

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Target: TAB1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJT-1744

Application*: WB

Datasheet SDS

Mouse Anti-TAB1 Recombinant Antibody (CBYJT-1743) (CBMAB-T0804-YJ)

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Target: TAB1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-1743

Application*: WB

Datasheet SDS

Mouse Anti-TAB1 Recombinant Antibody (CBYJT-1742) (CBMAB-T0803-YJ)

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Target: TAB1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-1742

Application*: WB

Datasheet SDS

Mouse Anti-TAB1 (AA 1-504) Recombinant Antibody (CBFYM-3153) (CBMAB-M3350-FY)

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Target: TAB1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYM-3153

Application*: WB-Ti, WB-Ce, E, WB-Re

Datasheet SDS

Mouse Anti-TAB1 Recombinant Antibody (CBT1181) (V2LY-0625-LY2966)

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Target: TAB1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Cattle, Dog, Pig

Clone: CBT1181

Application*: WB

Datasheet SDS

More Infomation

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion

IEImmunoelectrophoresis
IFImmunofluorescence
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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