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Mouse Anti-TAB1 Recombinant Antibody (CBYJT-1742) (CBMAB-T0803-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TAB1 (TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1). The antibody can be used for immunoassay techniques, such as WB.
See all TAB1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1742
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Purified recombinant human TAB1(N-terminal) protein fragments expressed in E. coli
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
100 mM Tris-glycine, 150 mM NaCl, pH 7.4, 50% Glycerol
Preservative
0.2% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
N-terminus

Target

Full Name
TAB1 Gene(Protein Coding) TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1
Introduction
TAB1 was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. TAB1 interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of it is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may play a role as a mediator between TGF beta receptors and TAK1. TAB1 can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli.
Entrez Gene ID
10454
UniProt ID
Q15750
Alternative Names
TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1; TAK1-Binding Protein 1; Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 1; Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 1; MAP3K7IP1; Transforming Growth Factor Beta-Activated Kinase-Binding Protein 1
Function
May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
Biological Process
Biological Process aorta developmentIEA:Ensembl
Biological Process cardiac septum developmentIEA:Ensembl
Biological Process coronary vasculature developmentIEA:Ensembl
Biological Process heart morphogenesisIEA:Ensembl
Biological Process in utero embryonic developmentIEA:Ensembl
Biological Process lung developmentIEA:Ensembl
Biological Process positive regulation of MAP kinase activityIEA:Ensembl
Biological Process positive regulation of protein serine/threonine kinase activityIDA:UniProtKB1 Publication
Biological Process transforming growth factor beta receptor signaling pathwayIEA:Ensembl
PTM
Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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