TADA3

DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. TADA3 is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which functions crucially in chromatin modulation and cell cycle progression. Along with the other components of the complex, it links transcriptional activators bound to specific promoters, to histone acetylation and the transcriptional machinery. It is also involved in the stabilization and activation of the p53 tumor suppressor protein that functions in the cellular response to DNA damage.

Full Name

TADA3

Function

Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Biological Process

Biological Process histone acetylationIC:ComplexPortal1 Publication
Biological Process histone H3 acetylationIDA:UniProtKB1 Publication
Biological Process histone H3-K14 acetylationIDA:ComplexPortal1 Publication
Biological Process intracellular estrogen receptor signaling pathwayTAS:UniProtKB1 Publication
Biological Process mitotic cell cycleIEA:Ensembl
Biological Process monoubiquitinated histone deubiquitinationIDA:ComplexPortal1 Publication
Biological Process monoubiquitinated histone H2A deubiquitinationIDA:ComplexPortal1 Publication
Biological Process positive regulation of DNA-templated transcriptionIDA:UniProtKB1 Publication
Biological Process positive regulation of gene expressionIMP:UniProtKB1 Publication
Biological Process regulation of cell cycleIMP:ComplexPortal1 Publication
Biological Process regulation of cell divisionIDA:ComplexPortal1 Publication
Biological Process regulation of DNA repairIC:ComplexPortal2 Publications
Biological Process regulation of DNA-templated transcriptionIMP:ComplexPortal1 Publication
Biological Process regulation of embryonic developmentIC:ComplexPortal
Biological Process regulation of histone deacetylationIMP:ComplexPortal1 Publication
Biological Process regulation of protein phosphorylationIEA:Ensembl
Biological Process regulation of protein stabilityIEA:Ensembl
Biological Process regulation of RNA splicingIC:ComplexPortal1 Publication
Biological Process regulation of transcription by RNA polymerase IIIDA:ComplexPortal2 Publications
Biological Process regulation of tubulin deacetylationIMP:ComplexPortal1 Publication

Cellular Location

Nucleus