TANK

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Full Name

TRAF family member associated NFKB activator

Function

Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989).
Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989).
Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989).
May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.

Biological Process

Biological Process cellular response to DNA damage stimulusIMP:UniProtKB1 Publication
Biological Process cellular response to interleukin-1IMP:UniProtKB1 Publication
Biological Process cellular response to ionizing radiationIMP:UniProtKB1 Publication
Biological Process cellular response to tumor necrosis factorIMP:UniProtKB1 Publication
Biological Process defense response to virusIC:ComplexPortal1 Publication
Biological Process I-kappaB kinase/NF-kappaB signalingIBA:GO_Central1 Publication
Biological Process negative regulation of I-kappaB kinase/NF-kappaB signalingIMP:UniProtKB1 Publication
Biological Process positive regulation of protein deubiquitinationIMP:UniProtKB1 Publication
Biological Process positive regulation of ubiquitin-specific protease activityIMP:UniProtKB1 Publication
Biological Process signal transductionTAS:ProtInc1 Publication
Biological Process type I interferon signaling pathwayIC:ComplexPortal1 Publication

Cellular Location

Cytoplasm

PTM

Phosphorylated by IKBKE.
(Microbial infection) Cleaved by encephalomyocarditis virus (EMCV) protease 3C (PubMed:26363073).
This cleavage allows the virus to disrupt the TANK-TBK1-IKKepsilon-IRF3 complex, thereby inhibiting the induction of the IFN-beta signal pathway (PubMed:28487378).
(Microbial infection) Cleaved by Seneca Valley virus protease 3C allowing the virus to suppress interferon type-I through both RIG-I and Toll-like receptor-dependent pathways.