Sign in or Register   Sign in or Register
  |  

Rabbit Anti-TANK Recombinant Antibody (EG1704) (CBMAB-EN2040-LY)

The product is antibody recognizes ITRAF. The antibody EG1704 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:10000.
See all TANK antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG1704
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:10000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human I-TRAF.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TRAF family member associated NFKB activator
Introduction
The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
Human10010
Mouse21353
Rat252961
UniProt ID
HumanQ92844
MouseP70347
RatQ8VDA2
Alternative Names
ITRAF; TRAF2; I-TRAF
Function
Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989).
Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989).
Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989).
May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.
Biological Process
Biological Process cellular response to DNA damage stimulusIMP:UniProtKB1 Publication
Biological Process cellular response to interleukin-1IMP:UniProtKB1 Publication
Biological Process cellular response to ionizing radiationIMP:UniProtKB1 Publication
Biological Process cellular response to tumor necrosis factorIMP:UniProtKB1 Publication
Biological Process defense response to virusIC:ComplexPortal1 Publication
Biological Process I-kappaB kinase/NF-kappaB signalingIBA:GO_Central1 Publication
Biological Process negative regulation of I-kappaB kinase/NF-kappaB signalingIMP:UniProtKB1 Publication
Biological Process positive regulation of protein deubiquitinationIMP:UniProtKB1 Publication
Biological Process positive regulation of ubiquitin-specific protease activityIMP:UniProtKB1 Publication
Biological Process signal transductionTAS:ProtInc1 Publication
Biological Process type I interferon signaling pathwayIC:ComplexPortal1 Publication
Cellular Location
Cytoplasm
PTM
Phosphorylated by IKBKE.
(Microbial infection) Cleaved by encephalomyocarditis virus (EMCV) protease 3C (PubMed:26363073).
This cleavage allows the virus to disrupt the TANK-TBK1-IKKepsilon-IRF3 complex, thereby inhibiting the induction of the IFN-beta signal pathway (PubMed:28487378).
(Microbial infection) Cleaved by Seneca Valley virus protease 3C allowing the virus to suppress interferon type-I through both RIG-I and Toll-like receptor-dependent pathways.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-TANK Recombinant Antibody (EG1704)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare