TAS1R3

TAS1R3 is a putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) and also to most of the 20 standard L-amino acids, but not to their D-enantiomers or other compounds. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.

Full Name

Taste Receptor, Type 1, Member 3

Function

Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity).
Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.

Biological Process

Biological Process detection of chemical stimulus involved in sensory perception of sweet tasteIDA:HGNC-UCL1 Publication
Biological Process G protein-coupled receptor signaling pathwayIC:HGNC-UCL1 Publication
Biological Process sensory perception of sweet tasteIDA:UniProtKB3 Publications
Biological Process sensory perception of umami tasteIDA:UniProtKB1 Publication

Cellular Location

Cell membrane

Topology

Extracellular: 21-570
Helical: 571-591
Cytoplasmic: 592-603
Helical: 604-624
Extracellular: 625-639
Helical: 640-660
Cytoplasmic: 661-682
Helical: 683-703
Extracellular: 704-729
Helical: 730-750
Cytoplasmic: 751-762
Helical: 763-783
Extracellular: 784-789
Helical: 790-810
Cytoplasmic: 811-852