TCEA2

The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

TCEA2 Gene(Protein Coding) Transcription Elongation Factor A2

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.

Biological Process DNA-templated transcriptionIBA:GO_Central1 Publication
Biological Process DNA-templated transcription elongationNAS:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process regulation of DNA-templated transcription elongationNAS:UniProtKB1 Publication
Biological Process transcription elongation by RNA polymerase II promoterIEA:InterPro

Nucleus