TFPI
This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization. [provided by RefSeq, Jul 2016]
Full Name
TFPI Gene(Protein Coding) Tissue Factor Pathway Inhibitor
Function
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
Biological Process
Biological Process blood coagulationSource:ProtInc1 Publication
Biological Process cellular response to steroid hormone stimulusSource:UniProtKB1 Publication
Biological Process negative regulation of blood coagulationSource:UniProtKB1 Publication
Biological Process cellular response to steroid hormone stimulusSource:UniProtKB1 Publication
Biological Process negative regulation of blood coagulationSource:UniProtKB1 Publication
Cellular Location
Isoform Alpha
Secreted
Isoform Beta
Microsome membrane
Secreted
Isoform Beta
Microsome membrane
PTM
O-glycosylated.
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Anti-TFPI antibodies
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CompareTarget: TFPI
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0249
Application*: F, IA, WB
Target: Tfpi
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYJT-2715
Application*: E, WB
Target: TFPI
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-2704
Application*: ED, P
Target: TFPI
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CB178A
Application*: ELISA, IHC, IF
Target: TFPI
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb354
Application*: FC, Immuno assays, WB
Target: TFPI
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-2709
Application*: E, IP, WB
Target: TFPI
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-2708
Application*: WB, IP
Target: TFPI
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2707
Application*: WB, IH
Target: TFPI
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2706
Application*: WB, IH
Target: TFPI
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 5138
Application*: E, WB
Target: TFPI
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-2705
Application*: WB, IH
Target: TFPI
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2703
Application*: WB
Target: TFPI
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2702
Application*: WB, IH
Target: TFPI
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-2701
Application*: E
Target: TFPI
Specificity: Human
Target: Tfpi
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Rat
Clone: CBYJT-2716
Application*: WB, IC, P, C, E, IP, IF, F
Target: Tfpi
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYJT-2714
Application*: WB
Target: Tfpi
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJT-2712
Application*: E
Target: Tfpi
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJT-2711
Application*: ED
Target: Tfpi
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJT-2710
Application*: EC
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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