Mouse Anti-TFPI Recombinant Antibody (CBYJT-2703) (CBMAB-T1891-YJ)

Name: Mouse Anti-TFPI Recombinant Antibody (CBYJT-2703)
SKU: CBMAB-T1891-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-2703

Application

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 29-304

More Infomation

Target

Full Name

TFPI Gene(Protein Coding) Tissue Factor Pathway Inhibitor

Introduction

TFPI is a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. TFPI inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization.

Entrez Gene ID

7035

UniProt ID

P10646

Alternative Names

Tissue Factor Pathway Inhibitor; Extrinsic Pathway Inhibitor; Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor); TFPI1; LACI; EPI; Lipoprotein-Associated Coagulation Inhibitor; Anti-Convertin; TFI

Function

Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.

Biological Process

Biological Process blood coagulationSource:ProtInc1 Publication
Biological Process cellular response to steroid hormone stimulusSource:UniProtKB1 Publication
Biological Process negative regulation of blood coagulationSource:UniProtKB1 Publication

Cellular Location

Isoform Alpha
Secreted
Isoform Beta
Microsome membrane

PTM

O-glycosylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

TFPI Matched Antibody Pair (1199) (CAT#: APMAB-1199LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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