TNFAIP8
TNFAIP8 (TNF Alpha Induced Protein 8) is a Protein Coding gene. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. Gene Ontology (GO) annotations related to TNFAIP8 include cysteine-type endopeptidase inhibitor activity involved in apoptotic process. An important paralog of TNFAIP8 is TNFAIP8L3.
Full Name
TNF Alpha Induced Protein 8
Function
Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
Biological Process
Biological Process negative regulation of apoptotic processSource:ProtInc1 Publication
Biological Process positive regulation of apoptotic processSource:UniProtKB1 Publication
Biological Process positive regulation of apoptotic processSource:UniProtKB1 Publication
Cellular Location
Cytoplasm
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Anti-TNFAIP8 antibodies
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Target: TNFAIP8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3646
Application*: E
Target: TNFAIP8
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-3645
Application*: P
Target: TNFAIP8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3644
Application*: E
Target: TNFAIP8
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-3643
Application*: P
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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