TRABD2A

TRABD2A (TraB Domain Containing 2A) is a Protein Coding gene. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling. Gene Ontology (GO) annotations related to TRABD2A include metalloendopeptidase activity and Wnt-protein binding. An important paralog of TRABD2A is TRABD2B.

Full Name

TraB Domain Containing 2A

Function

Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.

Biological Process

Biological Process head development Source:UniProtKB
Biological Process negative regulation of Wnt signaling pathway Source:UniProtKB1 Publication
Biological Process positive regulation of protein oxidation Source:ParkinsonsUK-UCLBy Similarity
Biological Process positive regulation of protein-containing complex assembly Source:ParkinsonsUK-UCLBy Similarity
Biological Process proteolysis Source:ParkinsonsUK-UCL1 Publication
Biological Process Wnt signaling pathway Source:UniProtKB-KW

Cellular Location

Cell membrane

Topology

Extracellular: 20-477
Helical: 478-498
Cytoplasmic: 499-505