Mouse Anti-TRABD2A Recombinant Antibody (CBYJT-4474) (CBMAB-T3977-YJ)

Name: Mouse Anti-TRABD2A Recombinant Antibody (CBYJT-4474)
SKU: CBMAB-T3977-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-4474

Application

Immunogen

Chinese hamster ovary cell line CHO-derived recombinant human Tiki1/TRABD2A, Met1-Met477, Accession # Q86V40

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, Trehalose

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-477

More Infomation

Target

Full Name

TraB Domain Containing 2A

Introduction

TRABD2A (TraB Domain Containing 2A) is a Protein Coding gene. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling. Gene Ontology (GO) annotations related to TRABD2A include metalloendopeptidase activity and Wnt-protein binding. An important paralog of TRABD2A is TRABD2B.

Entrez Gene ID

129293

UniProt ID

Q86V40

Alternative Names

TraB Domain Containing 2A; TRAB Domain-Containing Protein 2A; C2orf89; TIKI1; Chromosome 2 Open Reading Frame 89; UPF0632 Protein C2orf89; Metalloprotease TIKI1

Function

Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.

Biological Process

Biological Process head development Source:UniProtKB
Biological Process negative regulation of Wnt signaling pathway Source:UniProtKB1 Publication
Biological Process positive regulation of protein oxidation Source:ParkinsonsUK-UCLBy Similarity
Biological Process positive regulation of protein-containing complex assembly Source:ParkinsonsUK-UCLBy Similarity
Biological Process proteolysis Source:ParkinsonsUK-UCL1 Publication
Biological Process Wnt signaling pathway Source:UniProtKB-KW

Cellular Location

Cell membrane

Topology

Extracellular: 20-477
Helical: 478-498
Cytoplasmic: 499-505

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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