Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-TRABD2A Recombinant Antibody (CBYJT-4474) (CBMAB-T3977-YJ)


See all TRABD2A antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4474
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human Tiki1/TRABD2A, Met1-Met477, Accession # Q86V40
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, Trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-477

Target

Full Name
TraB Domain Containing 2A
Introduction
TRABD2A (TraB Domain Containing 2A) is a Protein Coding gene. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling. Gene Ontology (GO) annotations related to TRABD2A include metalloendopeptidase activity and Wnt-protein binding. An important paralog of TRABD2A is TRABD2B.
Entrez Gene ID
129293
UniProt ID
Q86V40
Alternative Names
TraB Domain Containing 2A; TRAB Domain-Containing Protein 2A; C2orf89; TIKI1; Chromosome 2 Open Reading Frame 89; UPF0632 Protein C2orf89; Metalloprotease TIKI1
Function
Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.
Biological Process
Biological Process head development Source:UniProtKB
Biological Process negative regulation of Wnt signaling pathway Source:UniProtKB1 Publication
Biological Process positive regulation of protein oxidation Source:ParkinsonsUK-UCLBy Similarity
Biological Process positive regulation of protein-containing complex assembly Source:ParkinsonsUK-UCLBy Similarity
Biological Process proteolysis Source:ParkinsonsUK-UCL1 Publication
Biological Process Wnt signaling pathway Source:UniProtKB-KW
Cellular Location
Cell membrane
Topology
Extracellular: 20-477
Helical: 478-498
Cytoplasmic: 499-505
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-TRABD2A Recombinant Antibody (CBYJT-4474)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry