TRIM52

TRIM52 (Tripartite Motif Containing 52) is a Protein Coding gene. It functions in positive regulation of NF-kappaB transcription factor activity. An important paralog of TRIM52 is TRIM41.

Full Name

tripartite motif-containing 52

Function

E3 ubiquitin-protein ligase (PubMed:27667714).
Positively regulates the NF-kappa-B signaling pathway (PubMed:27667714, PubMed:28073078).
(Microbial infection) Exhibits antiviral activity against Japanese encephalitis virus (JEV). Ubiquitinates the viral non-structural protein 2 (NS2A) and targets it for proteasome-mediated degradation.

Biological Process

Biological Process defense response to virus Source:UniProtKB1 Publication
Biological Process positive regulation of DNA-binding transcription factor activity Source:GO_Central1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB2 Publications
Biological Process positive regulation of NF-kappaB transcription factor activity Source:UniProtKB1 Publication
Biological Process protein autoubiquitination Source:UniProtKB1 Publication
Biological Process protein ubiquitination Source:UniProtKB1 Publication

Cellular Location

Cytoplasm
Cytoplasm, cytosol
Nucleus

PTM

Autoubiquitinated (PubMed:27667714).
Polyubiquitinated (PubMed:20596523, PubMed:27667714).
Undergoes extremely rapid proteolytic degradation by the proteasome (PubMed:31133683).