TTLL12
TTLL12 (Tubulin Tyrosine Ligase Like 12) is a Protein Coding gene. It has an ubiquitous expression in esophagus (RPKM 28.7), colon (RPKM 16.0) and 25 other tissues.
Full Name
Tubulin Tyrosine Ligase Like 12
Function
Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues (PubMed:20162578, PubMed:23251473).
Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) (PubMed:23251473).
Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability (PubMed:20162578, PubMed:23251473).
During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE (PubMed:28011935).
Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) (PubMed:23251473).
Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability (PubMed:20162578, PubMed:23251473).
During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE (PubMed:28011935).
Biological Process
Biological Process innate immune response Source:UniProtKB-KW
Biological Process negative regulation of type I interferon-mediated signaling pathway Source:UniProtKB1 Publication
Biological Process protein modification process Source:InterPro
Biological Process regulation of mitotic cell cycle Source:UniProtKB1 Publication
Biological Process negative regulation of type I interferon-mediated signaling pathway Source:UniProtKB1 Publication
Biological Process protein modification process Source:InterPro
Biological Process regulation of mitotic cell cycle Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Midbody
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, spindle
Nucleus
Predominantly localizes in the cytoplasm (PubMed:28011935).
Partially colocalizes with vimentin in prostate cancer cells (PubMed:20162578).
Midbody
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, spindle
Nucleus
Predominantly localizes in the cytoplasm (PubMed:28011935).
Partially colocalizes with vimentin in prostate cancer cells (PubMed:20162578).
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Anti-TTLL12 antibodies
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CompareTarget: TTLL12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBYJT-5171
Application*: F, IC, IF, IH, P, WB
Target: TTLL12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Rat, Monkey
Clone: CBYJT-5170
Application*: WB, IH, IF, F
Target: TTLL12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Dog, Rat, Monkey
Clone: CBYJT-5169
Application*: F, IF, IH, WB
Target: TTLL12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog
Clone: CBYJT-5168
Application*: WB, IH, IF, F
Target: TTLL12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-5167
Application*: F, IC, IF, IH, P, WB
Target: TTLL12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-5166
Application*: F, IF, IH, WB
Target: TTLL12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-5165
Application*: F, IC, IF, IH, P, WB
Target: TTLL12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5164
Application*: WB, F
Target: TTLL12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5163
Application*: F, IH, P, WB
Target: TTLL12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5162
Application*: F, IC, IF, WB
Target: TTLL12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7F11
Application*: F, IF, P, WB
Target: TTLL12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6E4
Application*: F, IF, P, WB
Target: TTLL12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5H3
Application*: IF, P, WB
Target: TTLL12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4E3
Application*: F, IF, P, WB
Target: TTLL12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4B2
Application*: F, IF, P, WB
Target: TTLL12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3H6
Application*: F, IF, P, WB
Target: TTLL12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2H10
Application*: F, P, WB
Target: TTLL12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D3
Application*: F, WB
Target: TTLL12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-53429
Application*: F, P, WB
Target: TTLL12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 12B7
Application*: F, IF, WB
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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