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TTLL12

TTLL12 (Tubulin Tyrosine Ligase Like 12) is a Protein Coding gene. It has an ubiquitous expression in esophagus (RPKM 28.7), colon (RPKM 16.0) and 25 other tissues.

Full Name

Tubulin Tyrosine Ligase Like 12

Function

Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues (PubMed:20162578, PubMed:23251473).
Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) (PubMed:23251473).
Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability (PubMed:20162578, PubMed:23251473).
During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE (PubMed:28011935).

Biological Process

Biological Process innate immune response Source:UniProtKB-KW
Biological Process negative regulation of type I interferon-mediated signaling pathway Source:UniProtKB1 Publication
Biological Process protein modification process Source:InterPro
Biological Process regulation of mitotic cell cycle Source:UniProtKB1 Publication

Cellular Location

Cytoplasm
Midbody
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, spindle
Nucleus
Predominantly localizes in the cytoplasm (PubMed:28011935).
Partially colocalizes with vimentin in prostate cancer cells (PubMed:20162578).

Anti-TTLL12 antibodies

Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5162) (CBMAB-T4741-YJ)

SDS

Target: TTLL12

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-5162

Application*: F, IC, IF, WB

Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5163) (CBMAB-T4742-YJ)

SDS

Target: TTLL12

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-5163

Application*: F, IH, P, WB

Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5164) (CBMAB-T4743-YJ)

SDS

Target: TTLL12

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-5164

Application*: WB, F

Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5165) (CBMAB-T4745-YJ)

SDS

Target: TTLL12

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJT-5165

Application*: F, IC, IF, IH, P, WB

Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5166) (CBMAB-T4746-YJ)

SDS

Target: TTLL12

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJT-5166

Application*: F, IF, IH, WB

Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5167) (CBMAB-T4747-YJ)

SDS

Target: TTLL12

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJT-5167

Application*: F, IC, IF, IH, P, WB

Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5168) (CBMAB-T4748-YJ)

SDS

Target: TTLL12

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Dog

Clone: CBYJT-5168

Application*: WB, IH, IF, F

Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5169) (CBMAB-T4749-YJ)

SDS

Target: TTLL12

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Dog, Rat, Monkey

Clone: CBYJT-5169

Application*: F, IF, IH, WB

Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5170) (CBMAB-T4750-YJ)

SDS

Target: TTLL12

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Dog, Rat, Monkey

Clone: CBYJT-5170

Application*: WB, IH, IF, F

Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5171) (CBMAB-T4751-YJ)

SDS

Target: TTLL12

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: CBYJT-5171

Application*: F, IC, IF, IH, P, WB

Mouse Anti-TTLL12 Recombinant Antibody (12B7) (CBMAB-K2234-LY)

SDS

Target: TTLL12

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 12B7

Application*: F, IF, WB

Mouse Anti-TTLL12 Recombinant Antibody (V2-53429) (CBMAB-K2235-LY)

SDS

Target: TTLL12

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: V2-53429

Application*: F, P, WB

Mouse Anti-TTLL12 Recombinant Antibody (1D3) (CBMAB-K2236-LY)

SDS

Target: TTLL12

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1D3

Application*: F, WB

Mouse Anti-TTLL12 Recombinant Antibody (2H10) (CBMAB-K2237-LY)

SDS

Target: TTLL12

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2H10

Application*: F, P, WB

Mouse Anti-TTLL12 Recombinant Antibody (3H6) (CBMAB-K2238-LY)

SDS

Target: TTLL12

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 3H6

Application*: F, IF, P, WB

Mouse Anti-TTLL12 Recombinant Antibody (4B2) (CBMAB-K2239-LY)

SDS

Target: TTLL12

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4B2

Application*: F, IF, P, WB

Mouse Anti-TTLL12 Recombinant Antibody (4E3) (CBMAB-K2240-LY)

SDS

Target: TTLL12

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 4E3

Application*: F, IF, P, WB

Mouse Anti-TTLL12 Recombinant Antibody (5H3) (CBMAB-K2241-LY)

SDS

Target: TTLL12

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5H3

Application*: IF, P, WB

Mouse Anti-TTLL12 Recombinant Antibody (6E4) (CBMAB-K2242-LY)

SDS

Target: TTLL12

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 6E4

Application*: F, IF, P, WB

Mouse Anti-TTLL12 Recombinant Antibody (7F11) (CBMAB-K2243-LY)

SDS

Target: TTLL12

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 7F11

Application*: F, IF, P, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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