TTLL12

TTLL12 (Tubulin Tyrosine Ligase Like 12) is a Protein Coding gene. It has an ubiquitous expression in esophagus (RPKM 28.7), colon (RPKM 16.0) and 25 other tissues.
Full Name
Tubulin Tyrosine Ligase Like 12
Function
Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues (PubMed:20162578, PubMed:23251473).
Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) (PubMed:23251473).
Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability (PubMed:20162578, PubMed:23251473).
During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE (PubMed:28011935).
Biological Process
Biological Process innate immune response Source:UniProtKB-KW
Biological Process negative regulation of type I interferon-mediated signaling pathway Source:UniProtKB1 Publication
Biological Process protein modification process Source:InterPro
Biological Process regulation of mitotic cell cycle Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Midbody
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, spindle
Nucleus
Predominantly localizes in the cytoplasm (PubMed:28011935).
Partially colocalizes with vimentin in prostate cancer cells (PubMed:20162578).
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Anti-TTLL12 antibodies

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Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5171) (CBMAB-T4751-YJ)

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Target: TTLL12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBYJT-5171
Application*: F, IC, IF, IH, P, WB
Datasheet SDS

Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5170) (CBMAB-T4750-YJ)

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Target: TTLL12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Rat, Monkey
Clone: CBYJT-5170
Application*: WB, IH, IF, F
Datasheet SDS

Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5169) (CBMAB-T4749-YJ)

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Target: TTLL12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Dog, Rat, Monkey
Clone: CBYJT-5169
Application*: F, IF, IH, WB
Datasheet SDS

Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5168) (CBMAB-T4748-YJ)

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Target: TTLL12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog
Clone: CBYJT-5168
Application*: WB, IH, IF, F
Datasheet SDS

Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5167) (CBMAB-T4747-YJ)

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Target: TTLL12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-5167
Application*: F, IC, IF, IH, P, WB
Datasheet SDS

Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5166) (CBMAB-T4746-YJ)

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Target: TTLL12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-5166
Application*: F, IF, IH, WB
Datasheet SDS

Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5165) (CBMAB-T4745-YJ)

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Target: TTLL12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-5165
Application*: F, IC, IF, IH, P, WB
Datasheet SDS

Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5164) (CBMAB-T4743-YJ)

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Target: TTLL12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5164
Application*: WB, F
Datasheet SDS

Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5163) (CBMAB-T4742-YJ)

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Target: TTLL12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5163
Application*: F, IH, P, WB
Datasheet SDS

Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5162) (CBMAB-T4741-YJ)

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Target: TTLL12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5162
Application*: F, IC, IF, WB
Datasheet SDS

Mouse Anti-TTLL12 Recombinant Antibody (7F11) (CBMAB-K2243-LY)

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Target: TTLL12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7F11
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-TTLL12 Recombinant Antibody (6E4) (CBMAB-K2242-LY)

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Target: TTLL12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6E4
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-TTLL12 Recombinant Antibody (5H3) (CBMAB-K2241-LY)

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Target: TTLL12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5H3
Application*: IF, P, WB
Datasheet SDS

Mouse Anti-TTLL12 Recombinant Antibody (4E3) (CBMAB-K2240-LY)

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Target: TTLL12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4E3
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-TTLL12 Recombinant Antibody (4B2) (CBMAB-K2239-LY)

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Target: TTLL12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4B2
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-TTLL12 Recombinant Antibody (3H6) (CBMAB-K2238-LY)

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Target: TTLL12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3H6
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-TTLL12 Recombinant Antibody (2H10) (CBMAB-K2237-LY)

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Target: TTLL12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2H10
Application*: F, P, WB
Datasheet SDS

Mouse Anti-TTLL12 Recombinant Antibody (1D3) (CBMAB-K2236-LY)

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Target: TTLL12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D3
Application*: F, WB
Datasheet SDS

Mouse Anti-TTLL12 Recombinant Antibody (V2-53429) (CBMAB-K2235-LY)

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Target: TTLL12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-53429
Application*: F, P, WB
Datasheet SDS

Mouse Anti-TTLL12 Recombinant Antibody (12B7) (CBMAB-K2234-LY)

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Target: TTLL12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 12B7
Application*: F, IF, WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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