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Mouse Anti-TTLL12 Recombinant Antibody (6E4) (CBMAB-K2242-LY)

This product is antibody recognizes TTLL12. The antibody 6E4 immunoassay techniques such as: FC, IF, IHC-P, WB.
See all TTLL12 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6E4
Antibody Isotype
IgG2a
Application
FC, IF, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Tubulin Tyrosine Ligase Like 12
Introduction
TTLL12 (Tubulin Tyrosine Ligase Like 12) is a Protein Coding gene.
Entrez Gene ID
UniProt ID
Alternative Names
Tubulin Tyrosine Ligase Like 12; Tubulin Tyrosine Ligase-Like Family; Member 12; Tubulin Tyrosine Ligase-Like Family Member 12; Tubulin--Tyrosine Ligase-Like Protein 12; DJ526I14.2; KIAA0153;
Function
Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues (PubMed:20162578, PubMed:23251473).
Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) (PubMed:23251473).
Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability (PubMed:20162578, PubMed:23251473).
During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE (PubMed:28011935).
Biological Process
Biological Process innate immune response Source:UniProtKB-KW
Biological Process negative regulation of type I interferon-mediated signaling pathway Source:UniProtKB1 Publication
Biological Process protein modification process Source:InterPro
Biological Process regulation of mitotic cell cycle Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Midbody
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, spindle
Nucleus
Predominantly localizes in the cytoplasm (PubMed:28011935).
Partially colocalizes with vimentin in prostate cancer cells (PubMed:20162578).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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