Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5166) (CBMAB-T4746-YJ)

Name: Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5166)
SKU: CBMAB-T4746-YJ
Rating: 5 (1 reviews)

See all TTLL12 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJT-5166

Application

FC, IF, IHC, WB

Immunogen

TTLL12 antibody was raised in mouse using a full length recombinant protein of human TTLL12 (NP_055955) produced in HEK293T cells, as the immunogen

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Tubulin Tyrosine Ligase Like 12

Introduction

TTLL12 (Tubulin Tyrosine Ligase Like 12) is a Protein Coding gene. It has an ubiquitous expression in esophagus (RPKM 28.7), colon (RPKM 16.0) and 25 other tissues.

Entrez Gene ID

23170

UniProt ID

Q14166

Alternative Names

Tubulin Tyrosine Ligase Like 12; Tubulin Tyrosine Ligase-Like Family, Member 12; Tubulin Tyrosine Ligase-Like Family Member 12; Tubulin--Tyrosine Ligase-Like Protein 12; DJ526I14.2; KIAA0153

Function

Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues (PubMed:20162578, PubMed:23251473).
Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) (PubMed:23251473).
Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability (PubMed:20162578, PubMed:23251473).
During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE (PubMed:28011935).

Biological Process

Biological Process innate immune response Source:UniProtKB-KW
Biological Process negative regulation of type I interferon-mediated signaling pathway Source:UniProtKB1 Publication
Biological Process protein modification process Source:InterPro
Biological Process regulation of mitotic cell cycle Source:UniProtKB1 Publication

Cellular Location

Cytoplasm
Midbody
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, spindle
Nucleus
Predominantly localizes in the cytoplasm (PubMed:28011935).
Partially colocalizes with vimentin in prostate cancer cells (PubMed:20162578).

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5166)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-TTLL12 Recombinant Antibody (3H6) (CAT#: CBMAB-K2238-LY)

Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5162) (CAT#: CBMAB-T4741-YJ)

Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5169) (CAT#: CBMAB-T4749-YJ)

Mouse Anti-TTLL12 Recombinant Antibody (5H3) (CAT#: CBMAB-K2241-LY)

Mouse Anti-TTLL12 Recombinant Antibody (4E3) (CAT#: CBMAB-K2240-LY)

Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5165) (CAT#: CBMAB-T4745-YJ)

Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5170) (CAT#: CBMAB-T4750-YJ)

Mouse Anti-TTLL12 Recombinant Antibody (12B7) (CAT#: CBMAB-K2234-LY)

Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5171) (CAT#: CBMAB-T4751-YJ)

Mouse Anti-TTLL12 Recombinant Antibody (CBYJT-5167) (CAT#: CBMAB-T4747-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry