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UBP1

Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.
Full Name
upstream binding protein 1 (LBP-1a)
Function
Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335).
Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293).
Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029).
Biological Process
Biological Process DNA repair Source:UniProtKB-KW
Biological Process monoubiquitinated protein deubiquitination Source:UniProtKB1 Publication
Biological Process positive regulation of error-prone translesion synthesis Source:Reactome
Biological Process protein deubiquitination Source:UniProtKB1 Publication
Biological Process regulation of DNA repair Source:UniProtKB1 Publication
Biological Process response to UV Source:UniProtKB1 Publication
Biological Process skeletal system development Source:Ensembl
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Cellular Location
Nucleus
PTM
Autocatalytic cleavage of USP1 following UV irradiation inactivates it, leading to an increase in ubiquitinated PCNA, recruitment of POLH and translesion synthesis.
Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment
Ubiquitinated by the CRL2(KLHDC2) complex following autocatalytic cleavage, leading to its degradation: the CRL2(KLHDC2) complex recognizes the diglycine (Gly-Gly) at the C-terminus.

Anti-UBP1 antibodies

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Target: UBP1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBCNC-724
Application*: WB
Target: UBP1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 1C5
Application*: WB, E
Target: UBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1G1
Application*: IP, E
Target: UBP1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBFYU-202
Application*: E, WB
Target: UBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYU-203
Application*: WB
Target: UBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 327C1a
Application*: DB, IF, WB, IC
Target: UBP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYU-205
Application*: IH
Target: UBP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYU-206
Application*: WB
Target: UBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYU-207
Application*: WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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