UBP1

Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.
Full Name
upstream binding protein 1 (LBP-1a)
Function
Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335).
Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293).
Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029).
Biological Process
Biological Process DNA repair Source:UniProtKB-KW
Biological Process monoubiquitinated protein deubiquitination Source:UniProtKB1 Publication
Biological Process positive regulation of error-prone translesion synthesis Source:Reactome
Biological Process protein deubiquitination Source:UniProtKB1 Publication
Biological Process regulation of DNA repair Source:UniProtKB1 Publication
Biological Process response to UV Source:UniProtKB1 Publication
Biological Process skeletal system development Source:Ensembl
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Cellular Location
Nucleus
PTM
Autocatalytic cleavage of USP1 following UV irradiation inactivates it, leading to an increase in ubiquitinated PCNA, recruitment of POLH and translesion synthesis.
Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment
Ubiquitinated by the CRL2(KLHDC2) complex following autocatalytic cleavage, leading to its degradation: the CRL2(KLHDC2) complex recognizes the diglycine (Gly-Gly) at the C-terminus.
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Anti-UBP1 antibodies

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Mouse Anti-UBP1 Recombinant Antibody (1C5) (CBMAB-A9741-LY)

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Target: UBP1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 1C5
Application*: WB, E
Datasheet SDS

Mouse Anti-UBP1 Recombinant Antibody (CBCNC-724) (CBMAB-C4408-CN)

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Target: UBP1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBCNC-724
Application*: WB
Datasheet SDS

Mouse Anti-UBP1 Recombinant Antibody (CBFYU-207) (CBMAB-U0207-FY)

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Target: UBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYU-207
Application*: WB
Datasheet SDS

Mouse Anti-UBP1 Recombinant Antibody (CBFYU-206) (CBMAB-U0206-FY)

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Target: UBP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYU-206
Application*: WB
Datasheet SDS

Mouse Anti-UBP1 Recombinant Antibody (CBFYU-205) (CBMAB-U0205-FY)

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Target: UBP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYU-205
Application*: IH
Datasheet SDS

Mouse Anti-UBP1 Recombinant Antibody (327C1a) (CBMAB-U0204-FY)

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Target: UBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 327C1a
Application*: DB, IF, WB, IC
Datasheet SDS

Mouse Anti-UBP1 Recombinant Antibody (CBFYU-203) (CBMAB-U0203-FY)

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Target: UBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYU-203
Application*: WB
Datasheet SDS

Mouse Anti-UBP1 Recombinant Antibody (CBFYU-202) (CBMAB-U0202-FY)

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Target: UBP1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBFYU-202
Application*: E, WB
Datasheet SDS

Mouse Anti-UBP1 Monoclonal Antibody (1G1) (CBMAB-0284-LY)

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Target: UBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1G1
Application*: IP, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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