UBR2

Proteolysis by the ubiquitin-proteasome system controls the concentration of many regulatory proteins. The selectivity of ubiquitylation is determined by ubiquitin E3 ligases, which recognize the substrate's destabilization signal, or degron. The E3 ligase UBR2 participates in the N-end rule pathway, which targets proteins bearing an N-terminal degron, or N-degron (Kwon et al., 2003 [PubMed 14585983]).[supplied by OMIM

Full Name

UBR2

Function

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (PubMed:15548684, PubMed:20835242).
Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity).
Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A (By similarity).
Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (PubMed:20298436).
Required for spermatogenesis, promotes, with Tex19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity).
Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retrotransposon mobilization (By similarity).
Catalyzes ubiquitination and degradation of the N-terminal part of NLRP1 following NLRP1 activation by pathogens and other damage-associated signals: ubiquitination promotes degradation of the N-terminal part and subsequent release of the cleaved C-terminal part of NLRP1, which polymerizes and forms the NLRP1 inflammasome followed by host cell pyroptosis (By similarity).

Biological Process

Biological Process cellular response to leucine Source:UniProtKB1 Publication
Biological Process heterochromatin formation Source:UniProtKB
Biological Process histone H2A ubiquitination Source:UniProtKB
Biological Process male meiosis I Source:Ensembl
Biological Process male meiotic nuclear division Source:UniProtKB
Biological Process negative regulation of TOR signaling Source:UniProtKB1 Publication
Biological Process negative regulation of transposition Source:UniProtKB
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process reciprocal meiotic recombination Source:UniProtKB
Biological Process spermatogenesis Source:UniProtKB
Biological Process ubiquitin-dependent protein catabolic process via the N-end rule pathway Source:GO_Central1 Publication

Cellular Location

Nucleus
Chromosome
Associated with chromatin during meiosis.