UBR3

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May play a role in Shh signaling by mediating the ubiquitination of Kif7 (By similarity). May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A (PubMed:27331610).

Full Name

Ubiquitin Protein Ligase E3 Component N-Recognin 3 (Putative)

Function

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity).
Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity).
May play a role in Shh signaling by mediating the ubiquitination of Kif7 (By similarity).
May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A (PubMed:27331610).

Biological Process

Biological Process embryo development ending in birth or egg hatching Source:UniProtKB
Biological Process negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Source:Ensembl
Biological Process positive regulation of protein catabolic process Source:Ensembl
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process sensory perception of smell Source:UniProtKB
Biological Process suckling behavior Source:UniProtKB
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB
Biological Process ubiquitin-dependent protein catabolic process via the N-end rule pathway Source:GO_Central1 Publication

Cellular Location

Membrane