UBR5

This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]

Full Name

Ubiquitin Protein Ligase E3 Component N-Recognin 5

Function

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity).
Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.

Biological Process

Biological Process cellular response to DNA damage stimulus Source:HGNC-UCL1 Publication
Biological Process DNA repair Source:UniProtKB-KW
Biological Process negative regulation of double-strand break repair Source:UniProtKB1 Publication
Biological Process negative regulation of histone H2A K63-linked ubiquitination Source:UniProtKB1 Publication
Biological Process positive regulation of canonical Wnt signaling pathway Source:BHF-UCL2 Publications
Biological Process positive regulation of gene expression Source:MGI1 Publication
Biological Process positive regulation of protein import into nucleus Source:BHF-UCL1 Publication
Biological Process progesterone receptor signaling pathway Source:HGNC-UCL1 Publication
Biological Process protein K48-linked ubiquitination Source:FlyBase1 Publication
Biological Process protein polyubiquitination Source:BHF-UCL2 Publications
Biological Process regulation of double-strand break repair Source:GO_Central1 Publication

Cellular Location

Nucleus