Human Recombinant UBR5 protein, His Tag (V2LY-0526-LY7521)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.
Biological Process DNA repair Source:UniProtKB-KW
Biological Process negative regulation of double-strand break repair Source:UniProtKB1 Publication
Biological Process negative regulation of histone H2A K63-linked ubiquitination Source:UniProtKB1 Publication
Biological Process positive regulation of canonical Wnt signaling pathway Source:BHF-UCL2 Publications
Biological Process positive regulation of gene expression Source:MGI1 Publication
Biological Process positive regulation of protein import into nucleus Source:BHF-UCL1 Publication
Biological Process progesterone receptor signaling pathway Source:HGNC-UCL1 Publication
Biological Process protein K48-linked ubiquitination Source:FlyBase1 Publication
Biological Process protein polyubiquitination Source:BHF-UCL2 Publications
Biological Process regulation of double-strand break repair Source:GO_Central1 Publication
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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