UCHL3

The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
Full Name
UCHL3
Function
Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.
Biological Process
Biological Process post-translational protein modification Source:Reactome
Biological Process protein catabolic process Source:UniProtKB1 Publication
Biological Process protein deubiquitination Source:UniProtKB2 Publications
Biological Process protein ubiquitination Source:Reactome
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Cellular Location
Cytoplasm
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Anti-UCHL3 antibodies

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Rabbit Anti-UCHL3 Recombinant Antibody (CBFYU-249) (CBMAB-U0249-FY)

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Target: UCHL3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: CBFYU-249
Application*: E, WB
Datasheet SDS

Rabbit Anti-UCHL3 Recombinant Antibody (CBFYU-248) (CBMAB-U0248-FY)

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Target: UCHL3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYU-248
Application*: E
Datasheet SDS

Rabbit Anti-UCHL3 Recombinant Antibody (CBFYU-247) (CBMAB-U0247-FY)

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Target: UCHL3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYU-247
Application*: E, WB
Datasheet SDS

Mouse Anti-UCHL3 Antibody (3C7) (CBMAB-1761CQ)

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Target: UCHL3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3C7
Application*: E, M
Datasheet SDS

Rabbit Anti-UCHL3 Recombinant Antibody (D25E6) (CBMAB-C4469-CN)

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Target: UCHL3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Cattle, Dog, Horse
Clone: D25E6
Application*: WB
Datasheet SDS

Mouse Anti-UCHL3 Recombinant Antibody (AF9G8) (CBMAB-C4468-CN)

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Target: UCHL3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: AF9G8
Application*: WB
Datasheet SDS

Mouse Anti-UCHL3 Recombinant Antibody (677710) (CBMAB-C4467-CN)

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Target: UCHL3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 677710
Application*: WB, IP
Datasheet SDS

Mouse Anti-UCHL3 Recombinant Antibody (4E9) (CBMAB-C4466-CN)

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Target: UCHL3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: 4E9
Application*: E, WB
Datasheet SDS

Rabbit Anti-UCHL3 Recombinant Antibody (204) (CBMAB-C4465-CN)

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Target: UCHL3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 204
Application*: P
Datasheet SDS

Rabbit Anti-UCHL3 Recombinant Antibody (153) (CBMAB-C4464-CN)

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Target: UCHL3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 153
Application*: WB, IP
Datasheet SDS

Mouse Anti-UCHL3 Recombinant Antibody (14e32) (CBMAB-C4463-CN)

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Target: UCHL3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: 14e32
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-UCHL3 Recombinant Antibody (10K29) (CBMAB-C4462-CN)

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Target: UCHL3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 10K29
Application*: WB
Datasheet SDS

Rabbit Anti-UCHL3 Recombinant Antibody (033) (CBMAB-C4461-CN)

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Target: UCHL3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 033
Application*: E
Datasheet SDS

Rabbit Anti-UCHL3 Recombinant Antibody (028) (CBMAB-C4460-CN)

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Target: UCHL3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: 028
Application*: E
Datasheet SDS

Rabbit Anti-UCHL3 Recombinant Antibody (007) (CBMAB-C4459-CN)

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Target: UCHL3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: 007
Application*: WB, E, P, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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