UGGT1

UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]

Full Name

UDP-Glucose Glycoprotein Glucosyltransferase 1

Function

Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.

Biological Process

Biological Process 'de novo' post-translational protein folding Source:UniProtKB1 Publication
Biological Process endoplasmic reticulum mannose trimming Source:Reactome
Biological Process ER-associated misfolded protein catabolic process Source:GO_Central1 Publication
Biological Process protein N-linked glycosylation via asparagine Source:GO_Central1 Publication

Cellular Location

Endoplasmic reticulum lumen
Endoplasmic reticulum-Golgi intermediate compartment