USP17L2

DUB3 is a member of the ubiquitin processing protease (UBP) subfamily of deubiquitinating enzymes.

Full Name

Ubiquitin Specific Peptidase 17-Like Family Member 2

Function

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors RIGI and IFIH1 stimulates the cellular response to viral infection.

Biological Process

Biological Process apoptotic process Source:UniProtKB-KW
Biological Process CAAX-box protein processing Source:UniProtKB1 Publication
Biological Process cell cycle Source:UniProtKB-KW
Biological Process MAPK cascade Source:Reactome
Biological Process negative regulation of GTPase activity Source:UniProtKB1 Publication
Biological Process negative regulation of histone deacetylation Source:UniProtKB1 Publication
Biological Process negative regulation of protein processing Source:UniProtKB1 Publication
Biological Process negative regulation of protein targeting to membrane Source:UniProtKB1 Publication
Biological Process positive regulation of GTPase activity Source:UniProtKB1 Publication
Biological Process positive regulation of MDA-5 signaling pathway Source:UniProtKB1 Publication
Biological Process positive regulation of RIG-I signaling pathway Source:UniProtKB1 Publication
Biological Process protein deubiquitination Source:UniProtKB1 Publication
Biological Process protein K48-linked deubiquitination Source:UniProtKB2 Publications
Biological Process protein K63-linked deubiquitination Source:UniProtKB1 Publication
Biological Process regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process regulation of cell migration Source:UniProtKB1 Publication
Biological Process regulation of cell population proliferation Source:UniProtKB1 Publication
Biological Process regulation of defense response to virus by host Source:UniProtKB1 Publication
Biological Process regulation of G2/MI transition of meiotic cell cycle Source:UniProtKB1 Publication
Biological Process regulation of ruffle assembly Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro

Cellular Location

Nucleus
Endoplasmic reticulum