VSIG4

This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Full Name
V-Set And Immunoglobulin Domain Containing 4
Function
Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.
Biological Process
Biological Process complement activation, alternative pathway Source:UniProtKB-KW
Biological Process negative regulation of complement activation, alternative pathway Source:UniProtKB1 Publication
Biological Process negative regulation of interleukin-2 production Source:GO_Central1 Publication
Biological Process negative regulation of macrophage activation Source:InterPro
Biological Process negative regulation of T cell proliferation Source:GO_Central1 Publication
Cellular Location
Membrane
Topology
Extracellular: 20-283
Helical: 284-304
Cytoplasmic: 305-399
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Anti-VSIG4 antibodies

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Rabbit Anti-VSIG4 Recombinant Antibody (202) (CBMAB-V0072-YC)

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Target: VSIG4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 202
Application*: E
Datasheet SDS

Rat Anti-VSIG4 Recombinant Antibody (NLA14) (CBMAB-V0004-YC)

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Target: VSIG4
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: NLA14
Application*: F
Datasheet SDS

Human Anti-VSIG4 Recombinant Antibody (
12D12) (V2LY-0725-LY1441)

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Target: VSIG4
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: 12D12
Application*: E
Datasheet SDS

Mouse Anti-VSIG4 Recombinant Antibody (3) (CBMAB-V0071-YC)

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Target: VSIG4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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