WLS

WLS (Wntless Wnt Ligand Secretion Mediator) is a Protein Coding gene. Diseases associated with WLS include Chromosome 1P32-P31 Deletion Syndrome and Chronic Intestinal Vascular Insufficiency. Among its related pathways are WNT ligand biogenesis and trafficking and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include signal transducer activity and mu-type opioid receptor binding.

Wntless Wnt Ligand Secretion Mediator

Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins (PubMed:34587386).
Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).

Biological Process anterior/posterior axis specification Source:UniProtKB
Biological Process cementum mineralization Source:Ensembl
Biological Process exocrine pancreas development Source:Ensembl
Biological Process hindbrain development Source:Ensembl
Biological Process intracellular protein transport Source:ParkinsonsUK-UCL1 Publication
Biological Process mesoderm formation Source:Ensembl
Biological Process midbrain development Source:Ensembl
Biological Process positive regulation of canonical Wnt signaling pathway Source:BHF-UCL1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB
Biological Process positive regulation of Wnt protein secretion Source:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of Wnt signaling pathway Source:ParkinsonsUK-UCL2 Publications
Biological Process Wnt protein secretion Source:WormBase1 Publication
Biological Process Wnt signaling pathway Source:UniProtKB

Golgi apparatus membrane
Cytoplasmic vesicle membrane
Cell membrane
Endoplasmic reticulum membrane
Golgi apparatus membrane
Early endosome membrane
Co-localizes with the adaptin AP2A2 at distinct punctae.

Zaki syndrome (ZKS):
An autosomal recessive disorder characterized by developmental delay, progressive microcephaly, and short stature, as well as dysmorphic features including sparse scalp hair, cupped ears, wide nose and mouth, short philtrum, and high-arched palate. Other variable features have been observed, including ocular, skeletal, cardiac, and renal anomalies.

Cytoplasmic: 1-15
Helical: 16-36
Lumenal: 37-232
Helical: 233-253
Cytoplasmic: 254-268
Helical: 269-289
Lumenal: 290-303
Helical: 304-324
Cytoplasmic: 325-331
Helical: 332-352
Lumenal: 353-380
Helical: 381-401
Cytoplasmic: 402-431
Helical: 432-452
Lumenal: 453-471
Helical: 472-492
Cytoplasmic: 493-541

N-glycosylated.