WWP2

Wwp2 is a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic sig

Full Name

WW Domain Containing E3 Ubiquitin Protein Ligase 2

Function

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.

Biological Process

Biological Process extracellular transport Source:UniProtKB1 Publication
Biological Process negative regulation of DNA-binding transcription factor activity Source:BHF-UCLBy Similarity
Biological Process negative regulation of DNA-templated transcription Source:BHF-UCLBy Similarity
Biological Process negative regulation of gene expression Source:UniProtKB1 Publication
Biological Process negative regulation of Notch signaling pathway Source:Reactome
Biological Process negative regulation of protein transport Source:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:BHF-UCL1 Publication
Biological Process negative regulation of transporter activity Source:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:Ensembl
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Biological Process protein autoubiquitination Source:FlyBase1 Publication
Biological Process protein K63-linked ubiquitination Source:UniProtKB
Biological Process protein modification process Source:ProtInc1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process protein ubiquitination Source:UniProtKB1 Publication
Biological Process regulation of ion transmembrane transport Source:BHF-UCL1 Publication
Biological Process regulation of membrane potential Source:BHF-UCL1 Publication
Biological Process regulation of potassium ion transmembrane transporter activity Source:BHF-UCL1 Publication
Biological Process transcription by RNA polymerase II Source:Ensembl
Biological Process viral entry into host cell Source:UniProtKB1 Publication

Cellular Location

Nucleus

PTM

Autoubiquitinated. Ubiquitinated by the SCF(FBXL15) complex, leading to its degradation by the proteasome.