Mouse Anti-WWP2 Recombinant Antibody (CBWJW-092) (CBMAB-W0243-WJ)

WW Domain Containing E3 Ubiquitin Protein Ligase 2

WWP2 is a protein-coding gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. Among its related pathways are SMAD Signaling Network and CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF). An important paralog of this gene is WWP1.

AIP2; WWp2-like

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.

Biological Process extracellular transport Source:UniProtKB1 Publication
Biological Process negative regulation of DNA-binding transcription factor activity Source:BHF-UCLBy Similarity
Biological Process negative regulation of DNA-templated transcription Source:BHF-UCLBy Similarity
Biological Process negative regulation of gene expression Source:UniProtKB1 Publication
Biological Process negative regulation of Notch signaling pathway Source:Reactome
Biological Process negative regulation of protein transport Source:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:BHF-UCL1 Publication
Biological Process negative regulation of transporter activity Source:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:Ensembl
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Biological Process protein autoubiquitination Source:FlyBase1 Publication
Biological Process protein K63-linked ubiquitination Source:UniProtKB
Biological Process protein modification process Source:ProtInc1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process protein ubiquitination Source:UniProtKB1 Publication
Biological Process regulation of ion transmembrane transport Source:BHF-UCL1 Publication
Biological Process regulation of membrane potential Source:BHF-UCL1 Publication
Biological Process regulation of potassium ion transmembrane transporter activity Source:BHF-UCL1 Publication
Biological Process transcription by RNA polymerase II Source:Ensembl
Biological Process viral entry into host cell Source:UniProtKB1 Publication

Nucleus

Autoubiquitinated. Ubiquitinated by the SCF(FBXL15) complex, leading to its degradation by the proteasome.