XCL2

Chemokine (C motif) ligand 2 (XCL2) is a small cytokine belonging to the XC chemokine family that is highly related to XCL1. It is predominantly expressed in activated T cells, but can also be found at low levels in unstimulated cells. XCL2 induces chemotaxis of cells expressing the chemokine receptor XCR1.

Full Name

X-C motif chemokine ligand 2

Function

Chemotactic activity for lymphocytes but not for monocytes or neutrophils.

Biological Process

Biological Process blood circulation Source:ProtInc1 Publication
Biological Process cellular response to interleukin-1 Source:GO_Central1 Publication
Biological Process cellular response to tumor necrosis factor Source:GO_Central1 Publication
Biological Process cellular response to type II interferon Source:GO_Central1 Publication
Biological Process chemokine-mediated signaling pathway Source:GO_Central1 Publication
Biological Process G protein-coupled receptor signaling pathway Source:GO_Central1 Publication
Biological Process inflammatory response Source:GO_Central1 Publication
Biological Process lymphocyte chemotaxis Source:GO_Central1 Publication
Biological Process monocyte chemotaxis Source:GO_Central1 Publication
Biological Process neutrophil chemotaxis Source:GO_Central1 Publication
Biological Process positive regulation of ERK1 and ERK2 cascade Source:GO_Central1 Publication
Biological Process positive regulation of GTPase activity Source:GO_Central1 Publication
Biological Process positive regulation of T cell chemotaxis Source:GO_Central1 Publication
Biological Process signal transduction Source:ProtInc1 Publication

Cellular Location

Secreted