ZAN
This gene encodes a sperm membrane protein that binds the zona pellucida of the egg in a species-specific manner. The encoded protein may be involved in signaling or gamete recognition. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
Full Name
zonadhesin
Function
Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.
Biological Process
Biological Process binding of sperm to zona pellucida Source:UniProtKB1 Publication
Biological Process cell-cell adhesion Source:UniProtKB1 Publication
Biological Process cell-cell adhesion Source:UniProtKB1 Publication
Cellular Location
Cell membrane
Exclusively on the apical region of the sperm head.
Exclusively on the apical region of the sperm head.
Topology
Extracellular: 18-2757
Helical: 2758-2778
Cytoplasmic: 2779-2812
Helical: 2758-2778
Cytoplasmic: 2779-2812
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Anti-ZAN antibodies
+ Filters
Target: ZAN
Sensitivity: 0.011 ng/mL
Detection Range: 0.02-6 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: ZAN
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: CBWJZ-013
Application*: WB
Target: ZAN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2B6
Application*: E, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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