ZBED1

This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It was earlier identified as a gene with similarity to Ac transposable elements, however, was found not to have transposase activity. Later studies show that this gene product is localized in the nucleus and functions as a transcription factor. It binds to DNA elements found in the promoter regions of several genes related to cell proliferation, such as histone H1, hence may have a role in regulating genes related to cell proliferation. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene. [provided by RefSeq, Jan 2010]

Zinc Finger BED-Type Containing 1

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA (PubMed:27068747).
This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12 (PubMed:12663651, PubMed:17209048, PubMed:17220279, PubMed:27068747).
The resulting increased transcriptional activity drives cell proliferation (PubMed:12663651, PubMed:17220279).
Binds to 5'-TGTCG[CT]GA[CT]A-3' consensus sequences in gene promoters of ribosomal proteins (PubMed:12663651, PubMed:17209048, PubMed:17220279, PubMed:27068747).
(Microbial infection) Binds to human adenovirus gene promoters and contributes to transcriptional repression and virus growth inhibition during early stages of infection.

Biological Process negative regulation by host of viral genome replication Source:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:NTNU_SB1 Publication
Biological Process protein autosumoylation Source:UniProtKB1 Publication
Biological Process regulation of DNA-templated transcription Source:UniProtKB2 Publications
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication

Nucleus, PML body
Nucleus
In granular structures.
Nucleus, PML body
(Microbial infection) Upon interaction with human adenovirus early E1A protein, the protein is redistributed to the peripheral areas of PML bodies.

Autosumoylated with SUMO1, SUMO2, and SUMO3.