Mouse Anti-ZBED1 Recombinant Antibody (2A7) (CBMAB-Z0063-WJ)

Name: Mouse Anti-ZBED1 Recombinant Antibody (2A7)
SKU: CBMAB-Z0063-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

2A7

Application

IF, IHC-P, WB

Immunogen

Full length human recombinant protein of human ZBED1(NP_004720) produced in HEK293T cell.

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

More Infomation

Target

Full Name

Zinc Finger BED-Type Containing 1

Introduction

This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It was earlier identified as a gene with similarity to Ac transposable elements, however, was found not to have transposase activity. Later studies show that this gene product is localized in the nucleus and functions as a transcription factor. It binds to DNA elements found in the promoter regions of several genes related to cell proliferation, such as histone H1, hence may have a role in regulating genes related to cell proliferation. Binds to 5'-TGTCG[CT]GA[CT]A-3' DNA elements found in the promoter regions of a number of genes related to cell proliferation. Binds to the histone H1 promoter and stimulates transcription.

Entrez Gene ID

9189

UniProt ID

O96006

Alternative Names

ALTE; DREF; hDREF; TRAMP

Function

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA (PubMed:27068747).
This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12 (PubMed:12663651, PubMed:17209048, PubMed:17220279, PubMed:27068747).
The resulting increased transcriptional activity drives cell proliferation (PubMed:12663651, PubMed:17220279).
Binds to 5'-TGTCG[CT]GA[CT]A-3' consensus sequences in gene promoters of ribosomal proteins (PubMed:12663651, PubMed:17209048, PubMed:17220279, PubMed:27068747).
(Microbial infection) Binds to human adenovirus gene promoters and contributes to transcriptional repression and virus growth inhibition during early stages of infection.

Biological Process

Biological Process negative regulation by host of viral genome replication Source:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:NTNU_SB1 Publication
Biological Process protein autosumoylation Source:UniProtKB1 Publication
Biological Process regulation of DNA-templated transcription Source:UniProtKB2 Publications
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication

Cellular Location

Nucleus, PML body
Nucleus
In granular structures.
Nucleus, PML body
(Microbial infection) Upon interaction with human adenovirus early E1A protein, the protein is redistributed to the peripheral areas of PML bodies.

PTM

Autosumoylated with SUMO1, SUMO2, and SUMO3.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

ZBED1 Matched Antibody Pair (1312) (CAT#: APMAB-1312LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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