ZBTB33

This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.
Full Name
zinc finger and BTB domain containing 33
Function
Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453).
Biological Process
Biological Process intracellular signal transduction Source:ProtInc1 Publication
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process Wnt signaling pathway Source:UniProtKB-KW
Cellular Location
Nucleus
Cytoplasm
Also cytoplasmic in cells grown at high densities.
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Anti-ZBTB33 antibodies

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Mouse Anti-ZBTB33 Recombinant Antibody (6F8) (CBMAB-K2280-LY)

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Target: ZBTB33
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human, Dog, Bird
Clone: 6F8
Application*: WB, IP, IF, P, E
Datasheet SDS

Mouse Anti-ZBTB33 Recombinant Antibody (12H) (CBMAB-K2276-LY)

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Target: ZBTB33
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human, Dog, Bird, Hamster
Clone: 12H
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-ZBTB33 Recombinant Antibody (CBLY1-182) (CBMAB-K2274-LY)

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Target: ZBTB33
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBLY1-182
Application*: WB
Datasheet SDS

Mouse Anti-ZBTB33 Recombinant Antibody (11D7) (CBMAB-Z0094-WJ)

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Target: ZBTB33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Human
Clone: 11D7
Application*: IP, WB
Datasheet SDS

Mouse Anti-ZBTB33 Recombinant Antibody (2B2) (CBMAB-Z0093-WJ)

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Target: ZBTB33
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2B2
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-ZBTB33 Recombinant Antibody (3A8) (CBMAB-Z0092-WJ)

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Target: ZBTB33
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3A8
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-ZBTB33 Recombinant Antibody (CBWJZ-044) (CBMAB-Z0091-WJ)

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Target: ZBTB33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJZ-044
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-ZBTB33 Recombinant Antibody (CBWJZ-043) (CBMAB-Z0090-WJ)

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Target: ZBTB33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBWJZ-043
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-ZBTB33 Recombinant Antibody (6F) (CBMAB-K2279-LY)

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Target: ZBTB33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Dog, Chicken, Human, Rabbit, Rat
Clone: 6F
Application*: E, F, IF, IP, WB
Datasheet SDS

Mouse Anti-ZBTB33 Recombinant Antibody (6A100) (CBMAB-K2278-LY)

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Target: ZBTB33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Dog, Chicken, Human, Rat
Clone: 6A100
Application*: IA, WB, IP, IF
Datasheet SDS

Mouse Anti-ZBTB33 Recombinant Antibody (2T15) (CBMAB-K2277-LY)

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Target: ZBTB33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Cat, Chicken, Hamster, Human, Rat
Clone: 2T15
Application*: IH, IP, WB
Datasheet SDS

Mouse Anti-ZBTB33 Recombinant Antibody (CBLY1-181) (CBMAB-K2273-LY)

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Target: ZBTB33
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLY1-181
Application*: WB, IP, IF, E
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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