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Mouse Anti-ZBTB33 Recombinant Antibody (CBWJZ-044) (CBMAB-Z0091-WJ)

This product is a mouse antibody that recognizes ZBTB33. The antibody CBWJZ-044 can be used for immunoassay techniques such as: ELISA, IF, IP, WB.
See all ZBTB33 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJZ-044
Antibody Isotype
IgG1
Application
ELISA, IF, IP, WB

Basic Information

Immunogen
His-tagged Kaiso fusion protein (Human) lacking the zinc finger region.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid

Target

Full Name
zinc finger and BTB domain containing 33
Introduction
ZBTB33 (Zinc Finger And BTB Domain Containing 33) is a Protein Coding gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. Diseases associated with ZBTB33 include Epithelial Malignant Thymoma and Dendritic Cell Thymoma.
Entrez Gene ID
10009
UniProt ID
Q86T24
Alternative Names
ZNF348; ZNF-kaiso
Function
Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453).
Biological Process
Biological Process intracellular signal transduction Source:ProtInc1 Publication
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process Wnt signaling pathway Source:UniProtKB-KW
Cellular Location
Nucleus
Cytoplasm
Also cytoplasmic in cells grown at high densities.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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