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ZFYVE19

Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.

Full Name

Zinc Finger FYVE-Type Containing 19

Function

Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.

Biological Process

Biological Process abscission Source:UniProtKB1 Publication
Biological Process cell division Source:UniProtKB-KW
Biological Process mitotic cytokinesis checkpoint signaling Source:UniProtKB1 Publication
Biological Process negative regulation of cytokinesis Source:UniProtKB1 Publication

Cellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cleavage furrow
Midbody, Midbody ring
Localizes mainly on centrosomes in interphase and early mitosis. Localizes at the cleavage furrow and midbody ring in late mitosis and cytokinesis.

Involvement in disease

Cholestasis, progressive familial intrahepatic, 9 (PFIC9):
An autosomal recessive form of progressive cholestasis, a disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease. PFIC9 onset is in infancy or early childhood.

PTM

Phosphorylated in vitro at Ser-22 by AURKB; however, phosphorylation at this site could not be confirmed in vivo.

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Anti-ZFYVE19 antibodies

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ZFYVE19 Matched Antibody Pair (1316) (APMAB-1316LY)

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Target: ZFYVE19

Specificity: Human

ZFYVE19 Matched Antibody Pair (1315) (APMAB-1315LY)

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Target: ZFYVE19

Specificity: Human

Rabbit Anti-ZFYVE19 Recombinant Antibody (CBWJZ-085) (CBMAB-Z0247-WJ)

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Target: ZFYVE19

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBWJZ-085

Application*: WB, F

Mouse Anti-ZFYVE19 Recombinant Antibody (CBWJZ-086) (CBMAB-Z0246-WJ)

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Target: ZFYVE19

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJZ-086

Application*: E, IC, WB

Mouse Anti-ZFYVE19 Recombinant Antibody (3G4-2B11) (CBMAB-Z0245-WJ)

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Target: ZFYVE19

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3G4-2B11

Application*: E, IP, WB

Mouse Anti-ZFYVE19 Recombinant Antibody (4D5-2D11) (CBMAB-Z0244-WJ)

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Target: ZFYVE19

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4D5-2D11

Application*: E, IF, WB

Mouse Anti-ZFYVE19 Monoclonal Antibody (3C5) (CBMAB-0383-LY)

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Target: ZFYVE19

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 3C5

Application*: IP, M, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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