ZFYVE19

Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.
Full Name
Zinc Finger FYVE-Type Containing 19
Function
Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.
Biological Process
Biological Process abscission Source:UniProtKB1 Publication
Biological Process cell division Source:UniProtKB-KW
Biological Process mitotic cytokinesis checkpoint signaling Source:UniProtKB1 Publication
Biological Process negative regulation of cytokinesis Source:UniProtKB1 Publication
Cellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cleavage furrow
Midbody, Midbody ring
Localizes mainly on centrosomes in interphase and early mitosis. Localizes at the cleavage furrow and midbody ring in late mitosis and cytokinesis.
Involvement in disease
Cholestasis, progressive familial intrahepatic, 9 (PFIC9):
An autosomal recessive form of progressive cholestasis, a disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease. PFIC9 onset is in infancy or early childhood.
PTM
Phosphorylated in vitro at Ser-22 by AURKB; however, phosphorylation at this site could not be confirmed in vivo.
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Anti-ZFYVE19 antibodies

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ZFYVE19 Matched Antibody Pair (1316) (APMAB-1316LY)

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Target: ZFYVE19
Specificity: Human
Datasheet SDS

ZFYVE19 Matched Antibody Pair (1315) (APMAB-1315LY)

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Target: ZFYVE19
Specificity: Human
Datasheet SDS

Rabbit Anti-ZFYVE19 Recombinant Antibody (CBWJZ-085) (CBMAB-Z0247-WJ)

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Target: ZFYVE19
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJZ-085
Application*: WB, F
Datasheet SDS

Mouse Anti-ZFYVE19 Recombinant Antibody (CBWJZ-086) (CBMAB-Z0246-WJ)

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Target: ZFYVE19
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJZ-086
Application*: E, IC, WB
Datasheet SDS

Mouse Anti-ZFYVE19 Recombinant Antibody (3G4-2B11) (CBMAB-Z0245-WJ)

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Target: ZFYVE19
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3G4-2B11
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-ZFYVE19 Recombinant Antibody (4D5-2D11) (CBMAB-Z0244-WJ)

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Target: ZFYVE19
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4D5-2D11
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-ZFYVE19 Monoclonal Antibody (3C5) (CBMAB-0383-LY)

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Target: ZFYVE19
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3C5
Application*: IP, M, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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