Sign in or Register
  • Home
  • ZFYVE19
  • Mouse Anti-ZFYVE19 Recombinant Antibody (CBWJZ-086)

Mouse Anti-ZFYVE19 Recombinant Antibody (CBWJZ-086) (CBMAB-Z0246-WJ)

See all ZFYVE19 antibodies
Go to compare Compare Online Inquiry
Datasheet
SDS
Request for COA
Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
CBWJZ-086
Application
ELISA, ICC, WB
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
More Infomation

Target

Full Name
Zinc Finger FYVE-Type Containing 19
Introduction
Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.
Entrez Gene ID
84936
UniProt ID
Q96K21
Alternative Names
FLJ14840
Function
Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.
Biological Process
Biological Process abscission Source:UniProtKB1 Publication
Biological Process cell division Source:UniProtKB-KW
Biological Process mitotic cytokinesis checkpoint signaling Source:UniProtKB1 Publication
Biological Process negative regulation of cytokinesis Source:UniProtKB1 Publication
Cellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cleavage furrow
Midbody, Midbody ring
Localizes mainly on centrosomes in interphase and early mitosis. Localizes at the cleavage furrow and midbody ring in late mitosis and cytokinesis.
Involvement in disease
Cholestasis, progressive familial intrahepatic, 9 (PFIC9):
An autosomal recessive form of progressive cholestasis, a disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease. PFIC9 onset is in infancy or early childhood.
PTM
Phosphorylated in vitro at Ser-22 by AURKB; however, phosphorylation at this site could not be confirmed in vivo.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-ZFYVE19 Recombinant Antibody (CBWJZ-086)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

ZFYVE19 Matched Antibody Pair (1315) (CAT#: APMAB-1315LY)

ZFYVE19 Matched Antibody Pair (1316) (CAT#: APMAB-1316LY)

Related Products

ZFYVE19 Matched Antibody Pair (1315) (CAT#: APMAB-1315LY)

Mouse Anti-ZFYVE19 Monoclonal Antibody (3C5) (CAT#: CBMAB-0383-LY)

Rabbit Anti-ZFYVE19 Recombinant Antibody (CBWJZ-085) (CAT#: CBMAB-Z0247-WJ)

ZFYVE19 Matched Antibody Pair (1316) (CAT#: APMAB-1316LY)

Mouse Anti-ZFYVE19 Recombinant Antibody (4D5-2D11) (CAT#: CBMAB-Z0244-WJ)

Mouse Anti-ZFYVE19 Recombinant Antibody (3G4-2B11) (CAT#: CBMAB-Z0245-WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry
Request bulk or custom quote Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry