ZNF207

Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).
Full Name
zinc finger protein 207
Function
Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440).
ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440).
Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187).
Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186).
According to another report, the stabilization is independent of the proteasome (PubMed:24462187).
Biological Process
Biological Process attachment of spindle microtubules to kinetochore Source:UniProtKB2 Publications
Biological Process cell division Source:UniProtKB-KW
Biological Process microtubule bundle formation Source:UniProtKB
Biological Process microtubule polymerization Source:UniProtKB
Biological Process mitotic sister chromatid segregation Source:UniProtKB2 Publications
Biological Process mitotic spindle assembly Source:UniProtKB1 Publication
Biological Process mitotic spindle assembly checkpoint signaling Source:UniProtKB2 Publications
Biological Process protein stabilization Source:UniProtKB2 Publications
Biological Process regulation of chromosome segregation Source:UniProtKB2 Publications
Cellular Location
Nucleus
Chromosome, centromere, kinetochore
Cytoplasm, cytoskeleton, spindle
Localizes primarily to the nucleus in interphase, concentrates at kinetochores prior to nuclear envelope breakdown and during early prometaphase, and disappears from kinetochores upon microtubule-binding.
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Anti-ZNF207 antibodies

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Mouse Anti-ZNF207 Recombinant Antibody (2D8) (CBMAB-0883-LY)

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Target: ZNF207
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2D8
Application*: IP, M
Datasheet SDS

Mouse Anti-ZNF207 Recombinant Antibody (1A7) (CBMAB-0882-LY)

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Target: ZNF207
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1A7
Application*: IP, M
Datasheet SDS

Mouse Anti-ZNF207 Recombinant Antibody (1A6) (CBMAB-0881-LY)

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Target: ZNF207
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1A6
Application*: IP, M
Datasheet SDS

Mouse Anti-ZNF207 Recombinant Antibody (10B2560) (CBMAB-Z0406-WJ)

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Target: ZNF207
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10B2560
Application*: E, IC, WB
Datasheet SDS

Mouse Anti-ZNF207 Recombinant Antibody (6D7) (CBMAB-Z0405-WJ)

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Target: ZNF207
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 6D7
Application*: E, IF, P, WB
Datasheet SDS

Mouse Anti-ZNF207 Recombinant Antibody (7G1) (CBMAB-Z0404-WJ)

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Target: ZNF207
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 7G1
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-ZNF207 Recombinant Antibody (5G6) (CBMAB-Z0403-WJ)

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Target: ZNF207
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5G6
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-ZNF207 Recombinant Antibody (5G3) (CBMAB-Z0402-WJ)

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Target: ZNF207
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5G3
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-ZNF207 Recombinant Antibody (8G7) (CBMAB-Z0401-WJ)

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Target: ZNF207
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 8G7
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-ZNF207 Recombinant Antibody (6H8) (CBMAB-Z0400-WJ)

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Target: ZNF207
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 6H8
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-ZNF207 Recombinant Antibody (6G11) (CBMAB-Z0399-WJ)

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Target: ZNF207
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 6G11
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-ZNF207 Recombinant Antibody (6D6) (CBMAB-Z0398-WJ)

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Target: ZNF207
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 6D6
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-ZNF207 Recombinant Antibody (V2-53841) (CBMAB-Z0397-WJ)

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Target: ZNF207
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: V2-53841
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-ZNF207 Recombinant Antibody (CBWJZ-121) (CBMAB-Z0396-WJ)

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Target: ZNF207
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJZ-121
Application*: WB, E, WB, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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