ZNF207

Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).

zinc finger protein 207

Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440).
ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440).
Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187).
Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186).
According to another report, the stabilization is independent of the proteasome (PubMed:24462187).

Biological Process attachment of spindle microtubules to kinetochore Source:UniProtKB2 Publications
Biological Process cell division Source:UniProtKB-KW
Biological Process microtubule bundle formation Source:UniProtKB
Biological Process microtubule polymerization Source:UniProtKB
Biological Process mitotic sister chromatid segregation Source:UniProtKB2 Publications
Biological Process mitotic spindle assembly Source:UniProtKB1 Publication
Biological Process mitotic spindle assembly checkpoint signaling Source:UniProtKB2 Publications
Biological Process protein stabilization Source:UniProtKB2 Publications
Biological Process regulation of chromosome segregation Source:UniProtKB2 Publications

Nucleus
Chromosome, centromere, kinetochore
Cytoplasm, cytoskeleton, spindle
Localizes primarily to the nucleus in interphase, concentrates at kinetochores prior to nuclear envelope breakdown and during early prometaphase, and disappears from kinetochores upon microtubule-binding.