ZNF683

Full Name

zinc finger protein 683

Function

Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T-cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Also plays a role in the differentiation of both thymic and peripheral NKT cells. Negatively regulates the accumulation of interferon-gamma (IFN-gamma) in NKT cells at steady state or after antigenic stimulation. Positively regulates granzyme B production in NKT cells after innate stimulation. Associates with the transcriptional repressor PRDM1/BLIMP1 to chromatin at gene promoter regions.
Isoform 1
Lacks transcriptional repressor activity. Binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Unable to regulate interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8+ T-cells.
Isoform 2
Transcriptional repressor that binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Regulates interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8+ T cells.

Biological Process

Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process cellular response to ionomycin Source:UniProtKB
Biological Process innate immune response Source:UniProtKB-KW
Biological Process negative regulation of transcription by RNA polymerase II Source:UniProtKB
Biological Process negative regulation of type II interferon production Source:UniProtKB
Biological Process positive regulation of gene expression Source:UniProtKB
Biological Process regulation of extrathymic T cell differentiation Source:UniProtKB
Biological Process regulation of gene expression Source:UniProtKB
Biological Process regulation of natural killer cell differentiation Source:UniProtKB
Biological Process regulation of natural killer cell differentiation involved in immune response Source:UniProtKB
Biological Process regulation of NK T cell differentiation Source:UniProtKB
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process T cell receptor signaling pathway Source:UniProtKB

Cellular Location

Nucleus