ZNF746

Transcription repressor that specifically binds to the 5-TATTTT[T/G]-3 consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.

Full Name

zinc finger protein 746

Function

Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.

Biological Process

Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of neuron death Source:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:ParkinsonsUK-UCL1 Publication
Biological Process protein heterooligomerization Source:UniProtKB1 Publication
Biological Process protein homooligomerization Source:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication

Cellular Location

Cytoplasm
Nucleus
Note: Mainly localizes to the cytoplasm; probably translocates to the nucleus to repress selected genes.

PTM

Ubiquitinated by PRKN. 'Lys-48'-linked polyubiquitination by PRKN leads to degradation by the proteasome and may play a key role in regulation of neuron death.