ZNF746

Transcription repressor that specifically binds to the 5-TATTTT[T/G]-3 consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.
Full Name
zinc finger protein 746
Function
Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.
Biological Process
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of neuron death Source:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:ParkinsonsUK-UCL1 Publication
Biological Process protein heterooligomerization Source:UniProtKB1 Publication
Biological Process protein homooligomerization Source:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Cellular Location
Cytoplasm
Nucleus
Note: Mainly localizes to the cytoplasm; probably translocates to the nucleus to repress selected genes.
PTM
Ubiquitinated by PRKN. 'Lys-48'-linked polyubiquitination by PRKN leads to degradation by the proteasome and may play a key role in regulation of neuron death.
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Anti-ZNF746 antibodies

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Mouse Anti-ZNF746 Recombinant Antibody (CBWJZ-239) (CBMAB-Z0652-WJ)

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Target: ZNF746
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mammalian
Clone: CBWJZ-239
Application*: IS, WB, IH
Datasheet SDS

Human ZNF746 ELISA Kit (V2LY-0626-LY5714)

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Target: ZNF746
Sensitivity: 0.0052 ng/mL
Detection Range: 0.01-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Mouse Anti-ZNF746 Recombinant Antibody (1D7) (CBMAB-0745-LY)

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Target: ZNF746
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1D7
Application*: IP, M
Datasheet SDS

Mouse Anti-ZNF746 Recombinant Antibody (1B7) (CBMAB-0744-LY)

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Target: ZNF746
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1B7
Application*: IP, M, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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